Results 51 to 60 of about 29,868,759 (307)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Automated snow avalanche monitoring for Austria: State of the art and roadmap for future work

Frontiers in Remote Sensing, 2023
Avalanches pose a significant threat to the population and infrastructure of mountainous regions. The mapping and documentation of avalanches in Austria is mostly done by experts during field observations and covers usually only specific localized areas.
Kathrin Lisa Kapper, Thomas Goelles , Thomas Goelles , Stefan Muckenhuber , Stefan Muckenhuber , Andreas Trügler , Andreas Trügler , Andreas Trügler , Jakob Abermann , Birgit Schlager , Birgit Schlager , Christoph Gaisberger , Markus Eckerstorfer , Jakob Grahn , Eirik Malnes , Alexander Prokop , Alexander Prokop , Wolfgang Schöner    +17 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Sentinel-1 Mission Status

Procedia Computer Science, 2016
AbstractAs part of the European Copernicus programme, the Sentinel-1 mission, based on a constellation of two SAR satellites, ensures continuity for Europe of C-band SAR observations. Sentinel-1A and Sentinel-1B were respectively launched from Kourou on 3rd April 2014 and 25th April 2016.Full Operations Capacity (FOC) of the mission is expected to be ...
Potin, Pierre, Rosich, Betlem, Miranda, Nuno, Grimont, Patrick   +3 more
openaire   +2 more sources

Interferometric Processing of Sentinel-1 TOPS Data [PDF]

IEEE Transactions on Geoscience and Remote Sensing, 2016
Sentinel-1 (S-1) has an unparalleled mapping capacity. In interferometric wide swath (IW) mode, three subswaths imaged in the novel Terrain Observation by Progressive Scans (TOPS) SAR mode result in a total swath width of 250 km. S-1 has become the European workhorse for large area mapping and interferometric monitoring at medium resolution.
Yague-Martinez, Nestor, Prats-Iraola, Pau, Rodriguez Gonzalez, Fernando, Brcic, Ramon, Shau, Robert, Geudtner, Dirk, Eineder, Michael, Bamler, Richard   +7 more
openaire   +2 more sources

Automating Chemical Reasoning in High‐Throughput Phase Identification With a Probabilistic, LLM‐Guided Framework

Advanced Science, EarlyView.
Autonomous laboratories can now synthesize materials faster than experts can interpret the resulting diffraction data. A probabilistic framework combines refinement‐fit metrics with large language model‐derived chemical reasoning to rank competing phase interpretations and flag those unsuitable for autonomous use.
Olympia Dartsi, Lauren N. Walters, Amalie E. Trewartha, Steven B. Torrisi, Amanda Volk, Liam Joyce, Gerbrand Ceder, Anubhav Jain   +7 more
wiley   +1 more source

Waterbody Detection and Reservoir Water Level Prediction Using Bayesian Mixture Models with Sentinel-1 GRD Data [PDF]

Geo Data
In this study, we used a Bayesian mixture model (BMM) to monitor water surface areas and estimate water levels in Yeongcheon Dam through Sentinel-1 synthetic aperture radar (SAR) imagery.
DongHyeon Yoon, Ha-Eun Yu, Euiho Hwang, Ki-mook Kang, Gibeom Nam, Jin-Gyeom Kim   +5 more
doaj   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

He Remade the Face of MU, 2010

, 2010
Headline of a March 5, 2010 article in the Milwaukee Journal Sentinel about the announcement of Robert A.
Milwaukee Journal Sentinel
core   +1 more source