Results 61 to 70 of about 21,391,424 (311)

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

A Fentanyl‐Responsive Microneedle Patch for Harm Reduction

Advanced Science, EarlyView.
A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao, Zerui Zhou, Tyler Wolter, Huanqing Niu, Yuanzhi Bian, Chixia Tian, Chun Xu, Chenming Zhang, Juhong Chen, Matthew W. Buczynski, Wujin Sun   +10 more
wiley   +1 more source

Waterbody Detection and Reservoir Water Level Prediction Using Bayesian Mixture Models with Sentinel-1 GRD Data [PDF]

Geo Data
In this study, we used a Bayesian mixture model (BMM) to monitor water surface areas and estimate water levels in Yeongcheon Dam through Sentinel-1 synthetic aperture radar (SAR) imagery.
DongHyeon Yoon, Ha-Eun Yu, Euiho Hwang, Ki-mook Kang, Gibeom Nam, Jin-Gyeom Kim   +5 more
doaj   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Landwirtschaftliche Flächennutzung (Rasterformat) : Deutschland-weite Karten der Hauptnutzungsklassen auf Basis von Sentinel-1, Sentinel-2 und Landsat Daten (2023) [PDF]

The dataset contains a map of the main classes of agricultural land use (dominant crop types and other land use types) in Germany for the year 2023. It complements a series of maps that are produced annually at the Thünen Institute beginning with the ...
Blickensdörfer, Lukas, Schwieder, Marcel, Tetteh, Gideon Okpoti, Gocht, Alexander, Erasmi, Stefan   +4 more
core   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Automatic detection of earthquake triggered landslides using Sentinel-1 SAR imagery based on deep learning

International Journal of Digital Earth
Earthquake Triggered Landslides (ETLs) are serious secondary hazards of earthquakes, causing severe casualties and property losses, and their rapid, automated and accurate detection is of great value. Due to the all-day and all-weather imaging capability
Lifu Chen, Zengqi Li, Chuang Song, Jin Xing, Xingmin Cai, Zhenhuan Fang, Ru Luo, Zhenhong Li   +7 more
doaj   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Combination of Linear Regression Lines to Understand the Response of Sentinel-1 Dual Polarization SAR Data with Crop Phenology—Case Study in Miyazaki, Japan

Remote Sensing, 2020
This study investigated the relationship between backscattering coefficients of a synthetic aperture radar (SAR) and the four biophysical parameters of rice crops—plant height, green vegetation cover, leaf area index, and total dry biomass. A paddy
Emal Wali, Masahiro Tasumi, Masao Moriyama   +2 more
doaj   +1 more source