Results 91 to 100 of about 20,649 (261)

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta, Ellen Brinza, Prateeti Khazanie, Pamela N. Peterson, P Michael Ho, David P. Kao   +5 more
wiley   +1 more source

Mapping Rice Fields in Urban Shanghai, Southeast China, Using Sentinel-1A and Landsat 8 Datasets

Remote Sensing, 2017
Sentinel-1A and Landsat 8 images have been combined in this study to map rice fields in urban Shanghai, southeast China, during the 2015 growing season.
Lamin R. Mansaray, Weijiao Huang, Dongdong Zhang, Jingfeng Huang, Jun Li   +4 more
doaj   +1 more source

Breast Cancer Outcomes From Ductal Carcinoma In Situ: A Population‐Based Cohort Study

International Journal of Cancer, EarlyView.
Women with ductal carcinoma in situ have an elevated risk of subsequent invasive breast cancer, but how this risk evolves over time is unclear. In this population‐based study of ethnically diverse women diagnosed between 2000 and 2022 in New Zealand, the risk of invasive ipsilateral breast cancer persisted beyond 5 years.
Qian Chen, Ian Campbell, Mark Elwood, Alana Cavadino, Phyu Sin Aye, Sandar Tin Tin   +5 more
wiley   +1 more source

Regulatory Effects of Ammonium Chloride in an In Vitro Model of Hepatic Encephalopathy: Mechanisms Involving ACTA2‐Mediated Cytoskeletal Remodeling

iLABMED, EarlyView.
Hyperammonemic stress suppresses ACTA2 expression and induces F‐actin cytoskeletal remodeling in astrocytes. The resulting inhibition of FAK/c‐Src signaling contributes to apoptosis, G2/M arrest, AQP4‐mediated swelling and junction‐associated proteins dysregulation, revealing a central role for ACTA2‐dependent cytoskeletal dysfunction in hepatic ...
Yue Tang, Jia Liu, Chengrong Bian, Wenwen Yuan, Wang Zhang, Fan Feng, Boan Li   +6 more
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

A New Faecal Immunochemical Test Buffer With Improved Haemoglobin Stability Under Varying Temperature and Storage Times

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigated faecal haemoglobin (f‐Hb) stability in a new faecal immunochemical test (FIT) buffer formulation, where fresh stool was incubated in buffer under varying temperature and time conditions. Relative to the buffer formulation currently in use (OC‐Sensor SOC3), the new formulation (OC‐Sensor SOC4) could retain more f‐Hb at higher ...
Rafha Rafeeu, Geraldine Laven‐Law, Jean M. Winter, Karen Wang, Rachel Parker, Graeme P. Young, Erin L. Symonds   +6 more
wiley   +1 more source

Post-seismic deformation mechanism of the July 2015 MW 6.5 Pishan earthquake revealed by Sentinel-1A InSAR observation. [PDF]

Sci Rep, 2020
Wang S, Zhang Y, Wang Y, Jiao J, Ji Z, Han M.   +5 more
europepmc   +1 more source