Results 121 to 130 of about 411,658 (298)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

OPTIMIZATION OF LAND USE MAPPING USING SENTINEL IMAGERY TO SUPPORT FLOOD DISASTER MITIGATION IN TORUE DISTRICT

GeoEco
To mitigate risk, effective land use planning must consider these socioeconomic factors. Numerous natural disasters will be brought on by improper land modification—the interaction between climate change and land-use change, such as deforestation ...
Widyastuti Widyastuti, Exsa Putra, Amalia Novarita, Rahmawati Rahmawati   +3 more
doaj   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Machine-Learning Crop-Type Mapping Sensitivity to Feature Selection and Hyperparameter Tuning

Remote Sensing
To improve crop yields and incomes, farmers consistently adapt their practices to climate and market fluctuations, resulting in highly variable crop field distribution and coverage in space and time.
Mayra Perez-Flores, Frédéric Satgé, Jorge Molina-Carpio, Renaud Hostache, Ramiro Pillco-Zolá, Diego Tola, Elvis Uscamayta-Ferrano, Lautaro Bustillos, Marie-Paule Bonnet, Celine Duwig   +9 more
doaj   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

“They say we're a rights‐respecting school but nobody knows what that really means”: Children's rights implementation in a Scottish secondary school

British Educational Research Journal, EarlyView.
Abstract Education has been an enduring feature of international human rights law since the Universal Declaration of Human Rights in 1948 and is the only human right that is compulsory for children. Appearing in all major human rights treaties, including the UN Convention on the Rights of the Child, education is multidimensional and a multiplier of ...
Amy Hanna
wiley   +1 more source

Using Sentinel Imagery for Mapping and Monitoring Small Surface Water Bodies

Remote Sensing
Increasing water demand and climate change exacerbate water management challenges in arid and semi-arid regions experiencing water scarcity resulting from low and irregular precipitation and high evapotranspiration.
Mariana Campista Chagas, Ana Paula Falcão, Rodrigo Proença de Oliveira   +2 more
doaj   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Land use and land cover change in East Java from 2015 to 2021: Use optical imagery and Google Earth engine

Environmental & Socio-economic Studies
This study analysed the changes in land use and land cover (LULC) in East Java Province by comparing two LULC maps interpreted from optical imagery. The images captured from 2015 to 2017 were selected to represent the initial LULC maps.
Mandala Marga, Indarto Indarto, Rodhi Nova Nevila, Saputra Akhmad Andi, Hakim Farid Lukman   +4 more
doaj   +1 more source

Sentinel school. [PDF]

Environmental Health Perspectives, 1996
openaire   +1 more source