Results 131 to 140 of about 411,658 (298)

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan   +4 more
wiley   +1 more source

Asymmetric Dialysis: Truly Unified and Simultaneous Single‐Pass Concentration and Buffer Exchange

open access: yesBiotechnology and Bioengineering, EarlyView.
Asymmetric dialysis, a novel one‐step continuous process combining ultrafiltration and diafiltration, achieves high product concentrations (up to 200 g/L) with low pressures and reduces buffer consumption by 75% compared to conventional methods. This sustainable, low‐cost technology demonstrates significant potential for integration into continuous ...
Ujwal Patil   +3 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

open access: yesBMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou   +6 more
wiley   +1 more source

Will the Real James Duncan Please Stand Up?

open access: yes, 2008
From 1956 through 1967 viewers enjoyed one of the most popular early television shows, To Tell the Truth. Host Bud Collyer would call on three contestants, standing side by side, to explain briefly who they were.
Glatfelter, Charles H., Motts, Wayne E.
core  

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

open access: yesBMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam   +4 more
wiley   +1 more source

The influence of rivers on seabird foraging ecology

open access: yesBiological Reviews, EarlyView.
ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais   +2 more
wiley   +1 more source

Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife

open access: yesBiological Reviews, EarlyView.
ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief   +4 more
wiley   +1 more source

Waders in a sea of debris: a global overview

open access: yesBiological Reviews, EarlyView.
ABSTRACT The impact of plastic pollution on ecosystems and marine fauna is well documented, although research into its effects on waders (also known as shorebirds) remains limited. Given that waders are exposed to coastal marine litter, this exposure could be a significant factor in the decline of their populations. This study aims to assess the global
Yada Trapletti‐Lanti   +3 more
wiley   +1 more source

Leading the Loop: Anchor‐Led Orchestration in Nascent Circular Ecosystems—A Qualitative Case Study

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The transition towards a circular economy necessitates coordinated, systemic change across value chains. Yet the role of anchor firms in initiating and orchestrating nascent circular ecosystems remains underexplored. Using an inductive, qualitative single‐case design, we analyse a German mid‐sized entrepreneurial firm, drawing on 21 interviews
Johann Felix Mader, Patrick Spieth
wiley   +1 more source

The Tree of Life Synagogue Attack: A Terrorist Radicalization Assessment Protocol‐18 Examination of Pre‐Attack Warnings and Post‐Attack Contagion and Copycat Effects

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT This is a retrospective case study of an antisemitic lone actor terrorist who completed the deadliest attack against the Jewish community in American history. The analysis through the lens of the Terrorist Radicalization Assessment Protocol (TRAP‐18) finds that 72% of the warning indicators were present, including four proximal warning ...
Molly Amman, Julia Kupper, J. Reid Meloy
wiley   +1 more source

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