Results 41 to 50 of about 85,786 (292)

Optimizing surveillance for livestock disease spreading through animal movements

, 2012
The spatial propagation of many livestock infectious diseases critically depends on the animal movements among premises; so the knowledge of movement data may help us to detect, manage and control an outbreak.
Bajardi, Paolo, Barrat, Alain, Colizza, Vittoria, Savini, Lara   +3 more
core   +3 more sources

Physician reports of medication use with explicit intention of hastening the end of life in the absence of explicit patient request in general practice in Belgium [PDF]

, 2010
Background: Although the incidence of the use of life-ending drugs without explicit patient request has been estimated in several studies, in-depth empirical research on this controversial practice is nonexistent.
Meeussen, Koen, Van den Block, Lieve, Bossuyt, Nathalie, Echteld, Michael, Bilsen, Johan, Deliens, Luc   +5 more
core   +3 more sources

Sentinel Surveillance for Enterovirus 71, Taiwan, 1998

Emerging Infectious Diseases, 1999
Outbreaks of enterovirus 71 have been reported around the world since 1969. The most recent outbreak occurred in Taiwan during April-July 1998. This hand, foot, and mouth disease epidemic was detected by a sentinel surveillance system in April at the beginning of the outbreak, and the public was alerted.
Trong-Neng Wu, Su-Fen Tsai, Shu-Fang Li, Tsuey-Fong Lee, Tzu-Mei Huang, Mei-Li Wang, Kwo-Hsiung Hsu, Chen-Yang Shen   +7 more
openaire   +3 more sources

Tracking Changes in SARS-CoV-2 Transmission with a Novel Outpatient Sentinel Surveillance System in Chicago, Illinois, USA

International Journal of Infectious Diseases, 2022
Purpose: Public health indicators typically used for monitoring the COVID-19 epidemic can be biased or lag behind changing community transmission patterns.
R. Richardson, P. Arevalo, E. Jorgensen, M. Pacilli, S. Lightner, S. Cobey, J. Gerardin   +6 more
doaj   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Deploying digital health data to optimize influenza surveillance at national and local scales.

PLoS Computational Biology, 2018
The surveillance of influenza activity is critical to early detection of epidemics and pandemics and the design of disease control strategies. Case reporting through a voluntary network of sentinel physicians is a commonly used method of passive ...
Elizabeth C Lee, Ali Arab, Sandra M Goldlust, Cécile Viboud, Bryan T Grenfell, Shweta Bansal   +5 more
doaj   +1 more source

Early warning of infectious disease outbreaks on cattle-transport networks.

PLoS ONE, 2021
Surveillance of infectious diseases in livestock is traditionally carried out at the farms, which are the typical units of epidemiological investigations and interventions.
Frederik Schirdewahn, Hartmut H K Lentz, Vittoria Colizza, Andreas Koher, Philipp Hövel, Beatriz Vidondo   +5 more
doaj   +1 more source

Productivity losses due to influenza and influenza-like illness in Switzerland: results of the Swiss Sentinel Surveillance Network in a non-pandemic era

Swiss Medical Weekly, 2021
BACKGROUND: The incidence of influenza and influenza-like illnesses in Switzerland is generally high. Although related direct medical costs can be substantial, especially if hospitalisations occur, several studies suggested that indirect costs due to ...
Yuki Tomonaga, Kyra Denise Zens, Phung Lang, Rita Born, Matthias Schwenkglenks, and the Swiss Sentinel Surveillance Network   +5 more
doaj   +1 more source

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source