Results 91 to 100 of about 2,215,497 (314)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Journal of Chemical and Petroleum Engineering, 2015 In this study, a three–layer \ artificial neural network (ANN) model was developed to predict the pressure gradient in horizontal liquid–liquid separated flow.
Sadra Azizi, Hajir Karimi
doaj +1 more source
Simulation of turbulent transonic separated flow over an airfoil [PDF]
A code developed for simulating high Reynolds number transonic flow fields of arbitrary configuration is described. This code, in conjunction with laboratory experiments, is used to devise and test turbulence transport models which may be suitable in the
Deiwert, G. S. +2 more
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
A three-dimensional turbulent separated flow and related mesurements [PDF]
The applicability of and the limits on the applicability of 11 near wall similarity laws characterizing three-dimensional turbulent boundary layer flows were determined.
Pierce, F. J.
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
NUMERICAL INVESTIGATION OF FLOW IN MIXED-FLOW PUMP WITH VOLUTE
TASK Quarterly, 2001 This work deals with modelling of flow in a complete mixed-flow pump with volute, including the tip leakage flows, using both the quasi-steady and true transient models of rotor/stator interaction.
MILAN SEDLAR
doaj
Fluctuations and massive separation in three-dimensional shock-wave/boundary-layer interactions [PDF]
Shock-wave unsteadiness was observed in rapidly compressed supersonic turbulent boundary layer flows with significant separation. A Mach 2.85 shock-wave/turbulent boundary layer flow was set up over a series of cylinder-flare bodies in the High Reynolds ...
Brown, J. D. +4 more
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source