Results 111 to 120 of about 2,215,497 (314)

An experimental documentation of a separated trailing-edge flow at a transonic Mach number [PDF]

open access: yes
A detailed experiment on the separated flow field at a sharp trailing edge is described and documented. The separated flow is a result of sustained adverse pressure gradients.
Brown, J. L., Viswanath, P. R.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Prediction of Pressure Drop for Oil–Water Flow in Horizontal Pipes using an Artificial Neural Network System

open access: yesJournal of Applied Fluid Mechanics, 2016
In this study, pressure drop for oil–water flow in horizontal pipes is represented by using artificial neural network (ANN). Results were compared with Al-Wahaibi correlation and Two-fluid model.
A. A. Amooey
doaj  

Pressure and thermal distributions on wings and adjacent surfaces induced by elevon deflections at Mach 6 [PDF]

open access: yes
Surface pressure distributions and heat transfer distributions were obtained on wing half-models in regions where three dimensional separated flow effects are prominent.
Johnson, C. B., Kaufman, L. G., II
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Use of surface heat transfer measurements as a flow separation diagnostic in a two dimensional reflected oblique shock/turbulent boundary layer interaction [PDF]

open access: yes
The feasibility of using streamwise surface heat transfer measurements to detect the presence of flow separation in a two-dimensional reflected oblique shock/turbulent boundary layer interaction is reported. Surface heat transfer and static pressure data
Hingst, Warren R., Porro, A. Robert
core   +1 more source

Computer program calculates velocities and streamlines in turbomachines [PDF]

open access: yes, 1968
Computer program calculates the velocity distribution and streamlines over widely separated blades of turbomachines. It gives the solutions of a two dimensional, subsonic, compressible nonviscous flow problem for a rotating or stationary circular cascade
Katsanis, T.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Summary of in-flight flow visualization obtained from the NASA high alpha research vehicle [PDF]

open access: yes
A summary of the surface and off-surface flow visualization results obtained in flight on the F-18 high alpha research vehicle (HARV) is presented, highlighting the extensive 3-D vortical flow on the aircraft at angles of attack up to 50 degs.
Delfrate, John H.   +2 more
core   +1 more source

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