Results 121 to 130 of about 2,215,497 (314)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
An analytical model for highly seperated flow on airfoils at low speeds [PDF]
A computer program was developed to solve the low speed flow around airfoils with highly separated flow. A new flow model included all of the major physical features in the separated region.
Naik, S. N., Zunnalt, G. W.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Crossflow effects on steady and fluctuating pressures on an ogive-cylinder cone-frustum model in supersonic separated flow [PDF]
Wind-tunnel tests were conducted on an ogive-cylinder model with two axisymmetric protuberances having cone frustum angles of cone = 23 deg and 45 deg that were used to generate detached shock waves and the resulting separated flow areas downstream of ...
Coe, C. F., Dods, J. B., Jr.
core +1 more source
Particle-laden weakly swirling free jets: Measurements and predictions [PDF]
A theoretical and experimental investigation of particle-laden, weakly swirling, turbulent free jets was conducted. Glass particles, having a Sauter mean diameter of 39 microns with a standard deviation of 15 microns, were used. A single loading ratio of
Cosman A.D.. +10 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Plume effects on the flow around a blunted cone at hypersonic speeds [PDF]
Tests at M = 8.2 show that a simulated rocket plume at the base of a blunted cone can cause large areas of separated flow, with dramatic effects on the heat transfer rate distribution.
Atcliffe, P., Kumar, D., Stollery, J. L.
core +1 more source
Instantaneous transport of a passive scalar in a turbulent separated flow. [PDF]
Environ Fluid Mech (Dordr), 2018 Ouro P +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Large-eddy simulations of separated flow and heat transfer in a rib-roughened channel
International Journal of ThermofluidsRibbed channel flows play a crucial role in various engineering systems where turbulence enhancement and improved heat transfer are required, such as in turbine blade cooling and combustor wall applications.
Himani Garg, Christer Fureby
doaj +1 more source