Results 61 to 70 of about 746,736 (269)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

APPLICABILITY OF THE OPEN SOURCE PACKAGE OPENFOAM FOR NUMERICAL MODELING SEPARATED FLOW AROUND AN AIRCRAFT AT SUBSONIC AND SUPERSONIC SPEEDS

Научный вестник МГТУ ГА, 2017
Applicability of the open source package OpenFOAM for numerical modeling different separated flows have been considered in the cases studies of the influence of vortices and their interaction with lifting surfaces, features of the flow field of rapidly ...
V. T. Kalugin, A. G. Golubev, A. S. Epikhin, A. A. Michkin   +3 more
doaj  

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Macrophage interaction of HDL subclasses separated by free flow isotachophoresis.

Journal of Lipid Research, 1990
Preparative isotachophoresis (ITP) was used for the fractionation of fasting and postprandial high density lipoproteins (HDL) according to their net charge in the absence of molecular sieve effects. Three major HDL subpopulations with fast, intermediate,
G Nowicka, T Brüning, A Böttcher, G Kahl, G Schmitz   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Numerical study of adaptive grids for laminar flow in a suddenly expanding channel

International Journal of Applied Mechanics and Engineering
In this article, a numerical study was carried out to study the dynamic adaptive grid method, based on the concept of the equidistribution method. The article explores a method for adapting the computational grid to solving two-dimensional Navier-Stokes ...
Bokhodir Kholboev
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Stochastic separated flow models with applications in numerical computations of supersonic particle-laden turbulent flows

Advances in Mechanical Engineering, 2015
In this article, three stochastic separated flow models were applied to predict the dispersion of inertial fuel particles in the supersonic turbulent flows.
Bing Wang, Zhaoxin Ren, Huiqiang Zhang
doaj   +1 more source

Experimental Study on Separated-flow Transition on a High-lift Blade [PDF]

Journal of Applied Fluid Mechanics
The increasing loading level for high-lift blades in low-pressure turbines leads to a laminar separation bubble (LSB) formed on the surface, resulting in a greater profile loss.
S. Yang, F. Tian, C. Teng, B. Xu
doaj   +1 more source