Results 61 to 70 of about 2,215,497 (314)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Numerical study of adaptive grids for laminar flow in a suddenly expanding channel

International Journal of Applied Mechanics and Engineering
In this article, a numerical study was carried out to study the dynamic adaptive grid method, based on the concept of the equidistribution method. The article explores a method for adapting the computational grid to solving two-dimensional Navier-Stokes ...
Bokhodir Kholboev
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Experimental Study on Separated-flow Transition on a High-lift Blade [PDF]

Journal of Applied Fluid Mechanics
The increasing loading level for high-lift blades in low-pressure turbines leads to a laminar separation bubble (LSB) formed on the surface, resulting in a greater profile loss.
S. Yang, F. Tian, C. Teng, B. Xu
doaj   +1 more source

Separated flow [PDF]

A brief overview of flow separation phenomena is provided. Langley has many active research programs in flow separation related areas. Three cases are presented which describe specific examples of flow separation research.
Dunham, R. E., Jr., Goodman, W. L., Howard, F. G., Margason, R. J., Rudy, D. H., Rumsey, C. L., Sellers, W. L., III, Stough, H. P., III, Thomas, J. L.   +8 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Stochastic separated flow models with applications in numerical computations of supersonic particle-laden turbulent flows

Advances in Mechanical Engineering, 2015
In this article, three stochastic separated flow models were applied to predict the dispersion of inertial fuel particles in the supersonic turbulent flows.
Bing Wang, Zhaoxin Ren, Huiqiang Zhang
doaj   +1 more source

Separated flow over bodies of revolution using an unsteady discrete-vorticity cross wake. Part 2: Computer program description [PDF]

A method is developed to determine the flow field of a body of revolution in separated flow. The computer was used to integrate various solutions and solution properties of the sub-flow fields which made up the entire flow field without resorting to a ...
Deffenbaugh, F. D., Marshall, F. J.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source