Results 81 to 90 of about 746,736 (269)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
VIBRATIONS OF THIN WINGS IN THE SEPARATED FLOW. CALCULATION AND EXPERIMENT
Научный вестник МГТУ ГА, 2016 The results of computational and experimental study of thin wings flutter in separated and unseparated flow are presented. The effect of flutter suppressing in the presence of separation is found.
V. V. Ovchinnikov, Yu. V. Petrov
doaj
Heuristics methods for the flow shop scheduling problem with separated setup times
Revista Produção Online, 2012 This paper deals with the permutation flow shop scheduling problem with separated machine setup times. As a result of an investigation on the problem characteristics, four heuristics methods are proposed with procedures of the construction sequencing ...
Marcelo Seido Nagano +1 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
NUMERICAL INVESTIGATION OF FLOW IN MIXED-FLOW PUMP WITH VOLUTE
TASK Quarterly, 2001 This work deals with modelling of flow in a complete mixed-flow pump with volute, including the tip leakage flows, using both the quasi-steady and true transient models of rotor/stator interaction.
MILAN SEDLAR
doaj
Journal of Chemical and Petroleum Engineering, 2015 In this study, a three–layer \ artificial neural network (ANN) model was developed to predict the pressure gradient in horizontal liquid–liquid separated flow.
Sadra Azizi, Hajir Karimi
doaj +1 more source