Results 141 to 150 of about 3,702,049 (302)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Signal Separation Based on Knowledge Representation
Applied SciencesThe separation of mixed signals typically requires appropriate prior assumptions, while traditional signal separation methods struggle to describe the differences in separation targets with significant features. This paper proposes a signal separation framework based on knowledge representation, where separation targets are represented with knowledge ...
Cai Lu, Xuyang Zou, Jingjing Zong
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Deep Clustering of Student Code Strategies Using Multi-View Code Representation (CMVAE)
Applied SciencesIn programming education, it is common for students to submit solutions to algorithmic problems that implement the same functionality but are not labeled, making it difficult to identify which codes employ similar strategies.
Zhengting Tang +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
, 2002 We investigate an N-state spin model called quantum relativistic Toda chain and based on the unitary finite dimensional representations of the Weyl algebra with q being N-th primitive root of unity.
Pakuliak, S., Sergeev, S.
core
Separable Representations of a W ∗ -Algebra [PDF]
Proceedings of the American Mathematical Society, 1970 openaire +1 more source
Separable and non-separable data representation for pattern discrimination
, 2015 We provide a complete work-flow, based on the language of quantum information theory, suitable for processing data for the purpose of pattern recognition. The main advantage of the introduced scheme is that it can be easily implemented and applied to process real-world data using modest computation resources.
openaire +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source