Results 151 to 160 of about 5,016,974 (324)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Separable Representations of a W ∗ -Algebra [PDF]
Proceedings of the American Mathematical Society, 1970 openaire +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Disentangled representations for improved generalisation in deep reinforcement learning [PDF]
Real-world environments are diverse and unpredictable, so Reinforcement Learning (RL) agents need to be robust to environment changes and adapt quickly.
Dunion, Mhairi
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Deep Clustering of Student Code Strategies Using Multi-View Code Representation (CMVAE)
Applied SciencesIn programming education, it is common for students to submit solutions to algorithmic problems that implement the same functionality but are not labeled, making it difficult to identify which codes employ similar strategies.
Zhengting Tang +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
On separated families of Anosov representations
We introduce different notions of separation for families of Anosov representations. We show that, along a diverging sequence of such families, the critical exponent is asymptotic to a combinatorial invariant computable from the spectral data of a finite graph. Our method allows us to derive bounds on the Thurston asymmetric metric.
Lejtreger, Joaquín, Lema, Joaquín
openaire +2 more sources
Shared or separated representations for letters with diacritics?
Psychonomic Bulletin & Review, 2018 F. Chetail, Emeline Boursain
semanticscholar +1 more source