Results 71 to 80 of about 957 (247)
On the depth of separating invariants for finite groups [PDF]
, 2012 . Consider a finite group G acting on a vector space V over a field k of characteristic p > 0. A separating algebra is a subalgebra A of the ring of invariants k[V]^G with the same point separation properties.
Elmer, J.
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3-Alterfolds and Quantum Invariants [PDF]
, 2023 In this paper, we introduce the concept of 3-alterfolds with embedded separating surfaces. When the separating surface is decorated by a spherical fusion category, we obtain quantum invariants of 3-alterfold, which is consistent with many topological ...
Wang, Yilong +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Finite separating sets and quasi-affine quotients [PDF]
, 2012 Nagata’s famous counterexample to Hilbert’s fourteenth problem shows that the ring of invariants of an algebraic group action on an affine algebraic variety is not always finitely generated. In some sense, however, invariant rings are not far from affine.
Dufresne, Emilie, Dufresne, E
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Separating invariants for two-dimensional orthogonal groups over finite fields [PDF]
, 2023 We described a minimal separating set for the algebra of $O(F_q)$-invariant polynomial functions of $m$-tuples of two-dimensional vectors over a finite field $F_q$.Comment: 8 ...
Lopatin, Artem +1 more
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