Results 121 to 130 of about 1,951,350 (319)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

High Coverage Sub‐Nano Iridium Cluster on Core–Shell Cobalt‐Cerium Bimetallic Oxide for Highly Efficient Full‐pH Water Splitting

Advanced Science
The construction of sub‐nanometer cluster catalysts (
Lili Zhang, Yuanting Lei, Yinze Yang, Dan Wang, Yafei Zhao, Xu Xiang, Huishan Shang, Bing Zhang   +7 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Separation of concerns in hybrid agent and component system

, 2010
Modularising requirements is a classic problem of software engineering; concerns often overlap, requiring multiple dimensions of decomposition to achieve separation.
Collier, Rem W., Jordan, Howell R., Rem W. Collier (12618934), Dragone, Mauro; id_orcid, Mauro Dragone (12618925), David Lillis (12618931), Jordan, Howell, Howell Jordan, Howell Jordan (12618928), Collier, Rem, Rem W. Collier, Mauro Dragone, Lillis, David, David Lillis, Dragone, Mauro   +14 more
core   +1 more source

Airborne Separation Assurance Systems: towards a work programme to prove safety [PDF]

, 2004
With Full Delegation Airborne Separation Assurance System (ASAS), separation control would be delegated to the (properly equipped) aircraft, i.e. aircraft pilots are responsible for aircraft separation.
Peter Brooker, Brooker, Peter
core   +1 more source

Whole genome data sequence for VIT_AJPSC phage against Shigella dysenteriae

BMC Research Notes
Objective Antibiotic resistance is one of the major causes of the increase in bacterial infections worldwilde. This is why it is the need of an hour to look for an alternative treatment; bacteriophage therapy is one of the most potent.
Aishwarya Srivastava, N. S. Jayaprakash
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Assessing the UK experience functional separation in fixed telecommunications markets

, 2008
This paper focuses on functional separation. After reviewing the literature on separation in its various guises and describing the circumstances that culminated in the creation of Openreach in the UK, the paper focuses on the implementation of the ...
Curwen, Peter, Curwen, P., Whalley, Jason, Whalley, J.   +3 more
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