Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Numerical Simulation Study on the Flow Field and Separation Efficiency by Built-In Twisted Tape in the Hydrocyclone. [PDF]
ACS Omega, 2023 Rao Y, Hu Y, Wang S, Zhao S, Zhou S.
europepmc +1 more source
Efficient risk sharing and separation
Journal of Economic TheoryzbMATH Open Web Interface contents unavailable due to conflicting licenses.
Abraham, Arpad J, Laczo, Sarolta
openaire +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
NUMERICAL INVESTIGATION OF LIQUID CARRYOVER IN T-JUNCTION WITH DIFFERENT DIAMETER RATIOS
Platform, a Journal of Engineering, 2017 T-junction is commonly used in distributing two-phase flow in a piping system, especially in oil and gas industries. In offshore Malaysia, T-junction is installed at the production header as a compact separator to tap produced gas from reservoir as fuel ...
Ahmed Saieed +3 more
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Even a little delocalization produces large kinetic enhancements of charge-separation efficiency in organic photovoltaics. [PDF]
Sci Adv, 2022 Balzer D, Kassal I.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Investigating the Effect of Flux on Ash Fusibility of High-Calcium Coal
ACS Omega, 2020 Jie Xu +3 more
doaj +1 more source
Recent Developments in Hydrocyclone Technology for Oil-in-Water Separation from Produced Water
EnergiesThe treatment of produced water is a major challenge faced by oil and gas industries worldwide. As a result of the increase in industrial activities, the generation of produced water has increased significantly. The most commonly used method for produced
Okwunna Maryjane Ekechukwu +2 more
doaj +1 more source