Results 71 to 80 of about 458,697 (317)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effect of Pre‐Filtration on Selective Isolation of Tat Protein by Affinity Membrane Separation: Analysis of Flux, Separation Efficiency, and Processing Time

open access: yes, 2007
The isolation and purification of Tat protein from bacterial lysate using avidin-biotin interaction in microfiltration membranes have been reported in the literature.
A. Nath   +9 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and Simulation of Fluid Separator for CO2 Flooding under Slug Flow

open access: yesShiyou jixie, 2020
During the oil production with the method of CO2 injection, overpressure casing gas is usually discharged into the production pipeline intermittently, which leads to the increase of gas-liquid ratio of produced fluid and even the formation of slug flow ...
Wang Xin   +4 more
doaj  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Structure Design and Optimization of Offshore Downhole Oil-Water Separation Hydrocyclone

open access: yesShiyou jixie, 2020
The continue increase of water content of offshore oilfields increases the burden of the oil production platform processing and the downhole lifting. It is necessary to carry out downhole oil-water separation researches for offshore high-water-cut oil ...
Ding Wengang   +6 more
doaj  

Efficient Speech Separation with Differencing

open access: yes
Given an input audio signal where multiple speakers talk over each other, the goal of speech separation is to recover the original signals of each speaker. In this paper we propose a novel sequence modelling method called relative context based on differencing and use it for a speech separation architecture called RCSep. The main advantages of relative
Joel Rixen, Matthias Renz
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Separation of Metal and Cathode Materials from Waste Lithium Iron Phosphate Battery by Electrostatic Process

open access: yes, 2023
The improper disposal of retired lithium batteries will cause environmental pollution and a waste of resources. In this study, a waste lithium iron phosphate battery was used as a raw material, and cathode and metal materials in the battery were ...
Haijun Bi   +4 more
core   +1 more source

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