Results 51 to 60 of about 173,349,195 (284)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Final Dispute Settlement in Numbers: Report of an Examination of Final Dispute Settlement in the Utrecht District Court

Transylvanian Review of Administrative Sciences, 2009
In the Netherlands the administrative court sometimes has the possibility to settle the case without jeopardizing the separation of administrative and judicial responsibilities based on the separation of powers doctrine.
Paulien WILLEMSEN, Rick BUSSCHER, Niels GROOT, Philip LANGBROEK, Linnea LANGERAK   +4 more
doaj   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Political and Administrative Dichotomy in South Africa: The Principle of Separation of Powers at Local Government Level

Acta Universitatis Danubius: Administratio, 2020
The study of political and administrative dichotomy in the discipline of public administration has always been about the differences that occur within the framework of government institutions.
Sihle Ashia Vilakazi, Toyin Cotties Adetiba   +1 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Separaţia puterilor in stat: teoria clasică nu mai exprimă realitatea politică [PDF]

Revista Institutului Naţional de Justiţie, 2016
The theory of separation of the three powers in the state has been for over two centuries. In different countries it has evolved in a different way. The author mentions the fact that even in the framework of the same state the separation of powers can ...
Moldoveanu Bianca
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

„Stará“ a „nová“ dělba moci: nový pohled na starý koncept

Časopis pro Právní Vědu a Praxi, 2018
Recenze publikací MÖLLERS, Christoph. The Three Branches. A Comparative Model of Separation of Powers. Oxford: Oxford University Press, 2013, 263 s. CAROLAN, Eoin. The New Separation of Powers. A Theory for Modern State. Oxford: Oxford University Press,
Adam Blisa
doaj  

Critical Reassessment of the Concept of Separation of Powers in the Legal-Political Thought of Imam Khomeini [PDF]

دانش حقوق عمومی
The idea of Islamic governance as proposed by Imam Khomeini fundamentally aligns with the practical wisdom of tradition; however, it is effectively shaped by concepts developed within the context of classical political thought and modern state theory ...
Zahra Sarempour, Mohamad Javaheri Tehrani   +1 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source