Results 71 to 80 of about 173,349,195 (284)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

The Prosecution of Public Figures and the Separation of Powers: Confusion within the Executive Branch [PDF]

open access: yes
Criminal investigation and prosecution of politicians, top civil servants and other public figures are topics frequently discussed in the media. The nature of the investigating or prosecuting authority varies between countries; from the general public ...
Anne van Aaken   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Politică versus Justiție sau o scurtă istorie a reformei magistraturii (Politics versus Justice or a short history of magistracy’s reform)

open access: yesPolis: Revista de Stiinte Politice, 2014
In a democratic society, the state is organized according to the classic principle of separation of powers. These powers are separated, but they should work together. To strengthen the rule of law in Romania, justice reform was essential.
Cristi DANILEȚ
doaj   +2 more sources

Arduous path to constitutionalism: Serbian constitutional developments in the first half of the nineteenth century [PDF]

open access: yesPravni Zapisi, 2019
Serbian nation building began in 1815, with the achievement of home rule. The Sultan granted autonomy to the Serbs in 1830 and the first constitutional ideas emerged immediately within the framework of designing autonomous institutions by the Serbs ...
Popović Dragoljub
doaj  

MEWUJUDKAN CHEKS AND BALANCES DALAM PENYUSUNAN UNDANG UNDANG

open access: yesMasalah-Masalah Hukum, 2013
The doctrine of separation of power and checks and balances in principle can be applied in a presidential system of government as a real son and only child of the doctrine of separation of powers, because outside the presidential system of government ...
Sulardi Sulardi
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Barnett presents on separation of powers challenges

open access: yes, 2014
Assistant Professor Kent Barnett presented his paper The Case for Judicial Review of Separation-of-Powers Challenges at the Summer Workshop Series at The Ohio State University Moritz College of Law during ...
Office of Communications and Public Relations
core   +2 more sources

New challenges to the separation of powers: the role of constitutional courts

open access: yes, 2020
The papers investigate the current challenge to the separation of power doctrine following the legal theory of an Italian constitutional scholar, Giovanni Bognetti. According to his theory, The Separation of powers is strictly linked with the particular
L. P. Vanoni
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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