Results 171 to 180 of about 302,470 (301)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bäcklund transformation for the first flows of the relativistic Toda hierarchy and associated properties

Open Physics, 2013
Choudhury Anindya
doaj   +1 more source

Nanofiltration concentration process of Ganoderma lucidum glycopeptides and membrane fouling mechanism based on the ultrasonic-regulated adsorption and concentration kinetics. [PDF]

Ultrason Sonochem
Xing D, Ma Y, Zhang Z, Hu S, Xue S, Cheng L, Zhou Y, Chen W, Zhi X, Li C.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Exact Bounded Solution to an Initial Boundary Value Problem for 1D Hyperbolic Equation with Interior Degeneracy. I. Separation of Variables

Journal of Optimization, Differential Equations and Their Applications, 2020
Vladimir L. Borsch, Peter I. Kogut
doaj   +1 more source

Good things come in threes: evaluating clinical utility of machine learning-derived clusters. [PDF]

JAMIA Open
Lisik D, De Kok JWTM, Bermúdez Barón N, Vanfleteren LEGW, Nwaru BI, Basna R.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Clinical Implications of ChatGPT-assisted Multimodal Pre-operative Assessment in Elderly Pertrochanteric Fracture Patients: An Exploratory Study. [PDF]

J Orthop Case Rep
Noda M, Takahara S, Hayashi S, Inui A, Oe K, Matsushita T.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Method for solving mixed boundary value problems for parabolic type equations by using modifications Lagrange-Sturm-Liouville operators

Modern Mathematical Methods
A new method for solving a mixed boundary value problem with a parabolic type equation is obtained. Boundary conditions of the third kind are considered. The inhomogeneity of the equation and the initial conditions of the problem are arbitrary continuous
Alexandr Trynin
doaj