Results 191 to 200 of about 166,676,583 (294)

Application of dimensionality reduction and clustering techniques for the analysis of Carrion's disease cases in the period 2000-2024. [PDF]

Front Artif Intell
Evangelista Gamarra M, Chancan Labajos JA, Figueroa Rosas PE, Alvarez Manrique RE.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Anterior component separation for complex ventral hernias: outcomes of a tailored reconstruction strategy. [PDF]

Front Surg
Edizsoy A, Karslı K, Akalın S, Tunçyürek P.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi response. [PDF]

Immunol Res
Dos Santos Rodrigues PAS, Brandão KM, de Sá Garcia Landeiro L, Calmon LC, de Oliveira AL, Miranda TB, de Araújo JLF, Veiga RV, de Figueiredo CAV, de Moura Santos P, Dos Santos Costa R.   +10 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Physiological Phenotypes in Comatose ICU Patients: A Retrospective Multidimensional Analysis. [PDF]

Diagnostics (Basel)
Bogdan PM, Pleșea-Condratovici A, Bogdan-Goroftei RE, Duceac LD, Armencia AO, Dabija MG, Salim C, Dabija VA, Nicolcescu P, Cristescu-Budală CL, Barbu ER, Calin AM.   +11 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Rapid Geographical Discrimination of Wenzhou Ougan via GC-IMS: A Comparison of Peel and Juice Volatile Fingerprints. [PDF]

Sensors (Basel)
Tang Y, Chen Z, Huo Z, Shi T, Hong X.
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source