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Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source
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On separation performance enhancement in convolutive blind source separation

2008 42nd Asilomar Conference on Signals, Systems and Computers, 2008
In this paper we present a method for estimating the bin-wise separation performance in convolutive blind source separation. A common way to separate convolutive mixtures is the transformation to the time-frequency domain and the separation of the single bins using an instantaneous ICA algorithm. This approach reduces the complexity but leads to the so-
Radoslaw Mazur, Alfred Mertins
openaire   +1 more source

Flow and Separation Performance of Supersonic Gas Separator

Applied Mechanics and Materials, 2014
A study on the flow and separation performance of supersonic gas separator is carried out through numerical simulation and experimentation. The effect of area ratio on the separation performance under low pressure ratio has been researched. The simulation results indicate that with an increase of the area ratio AR, the intensity of the shockwave ...
Jian Hua Zhao, Pei Qi Liu, Da Peng Hu
openaire   +1 more source

High-Performance Chromatographic Separation of Cerebrosides

2023
High-performance thin layer chromatography (HPTLC) is a very robust, fast, and inexpensive technique that enables separation of complex mixtures. Here, we describe the analytical separation of glucosylceramide and galactosylceramide by HPTLC. This technique can be used for quantitation purposes but also with small modification for subsequent mass ...
openaire   +2 more sources

Skill and Motivation as Separable Components of Performance

Perceptual and Motor Skills, 1965
A music learning experiment was performed, illustrating the possibility of isolating certain components of performance (labeled Skill and Motivation) by using separate measurement situations for each. Straightforward application of Hullian theory—which considers that component factors of performance interact prior to overt behavior and are not thus ...
openaire   +2 more sources

High-Performance Chromatographic Separation of Cerebrosides

2017
High-performance thin-layer chromatography (HPTLC) is a very robust, fast, and inexpensive technique that enables separation of complex mixtures. Here, we describe the analytical separation of glucosylceramide and galactosylceramide by HPTLC. This technique can be used for quantitation purposes but also with small modification for subsequent mass ...
Renaud, Sicard, Ralf, Landgraf
openaire   +2 more sources

Separable connector switching performance

IEEE Transactions on Power Delivery, 1990
Laboratory loadbreak testing of 25 kV class separable insulated connectors suggests that switching reliability achieved in the field will vary between 93.5% and 99.9% depending on the type of tool used, the condition of the connector system, the circuit voltage and loading, and ground plane proximity. A survey of user reliability requirements concluded
R. Filter, A.S. Jones
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The separating performance of fractionating columns

Recueil des Travaux Chimiques des Pays-Bas, 1964
AbstractThe definitions of theoretical plate and separating power are discussed, and the concept of “plate equivalency”, now called the “separating performance” of a fractionating column, is worked out.The separating performance is a dimensionless measure for the actual separation (the separating effect) obtained under conditions of partial reflux, as ...
H. G. Haring, H. W. Knol
openaire   +1 more source

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