FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Life course trajectory segregation and political polarization in contemporary Sweden. [PDF]
Nat CommunMalmberg B +2 more
europepmc +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Robust Bayesian hypothesis testing with the hierarchical EZ-DDM. [PDF]
Behav Res MethodsChávez De la Peña AF +2 more
europepmc +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Department of Applied Mathematics and Statistics newsletter, January 29, 2024
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
core
A Two-Step Estimation Approach of Latent Class-Item Response Theory Models in the Presence of DIF and Multidimensionality. [PDF]
Educ Psychol MeasBakk Z, Fabbricatore R.
europepmc +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Department of Applied Mathematics and Statistics Newsletter, August 25, 2025
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
core
A novel fluoride tray-assisted workflow for artificial intelligence-driven automated maxillary gingival segmentation on cone beam CT. [PDF]
Dentomaxillofac RadiolPapasratorn D +3 more
europepmc +1 more source