FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Rasch Analysis of General Self-Efficacy Among Individuals with Intellectual Disabilities. [PDF]
Behav Sci (Basel)Park EY.
europepmc +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
The latent structure of ICD-11 Prolonged Grief: Replicated factor mixture models in two national cohorts. [PDF]
PLOS Ment HealthCunningham J, Shevlin M, McElroy E.
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Use of Kaplan-Meier and Cox regressions in the distribution of length of stay in animal shelters for pre-specified calendar periods: Definition, computation, and examples of dog length of stay in orange county California. [PDF]
PLoS OneMavrovouniotis ML.
europepmc +1 more source
Image separation statistics for multiply imaged quasars
The Astrophysical Journal, 1984 openaire +1 more source
Blind source separation-semiparametric statistical approach
Blind source separation-semiparametric statistical approachThe semiparametric statistical model is used to formulate the problem of blind source separation. The method of estimating functions is applied to this problem. It is shown that an estimator of the mixing matrix or its learning version can be described in terms of an estimating function. The statistical efficiencies of these algorithms are studied. The
openaire
Active source selection using gap statistics for underdetermined blind source separation
, 2003 Yulei Luo, Jonathon A. Chambers
openalex +2 more sources