Results 31 to 40 of about 37,477 (255)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Para um aprofundamento historiográfico: discutindo o separatismo paulista de 1887

Revista Brasileira de História, 1999
Tendo como base pesquisa empírica realizada sobre o separatismo paulista de 1887, este artigo pretende colocar em discussão características que foram atribuídas ao movimento: sua estrita ligação ao republicanismo e seu caráter escravocrata.
Cássia Chrispiniano Adduci
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

‘I don't think I can catch it’: women, confidence and responsibility in football coach education [PDF]

, 2011
Whilst women’s participation in sport continues to increase, their presence remains ideologically challenging given the significance of sport for the construction of gendered identities.
Bains J., Benwell B., Beth Fielding‐Lloyd, Football Association, Foucault M., Foucault M., Gumperz J., Knoppers A., Knoppers A., Lindsey Meân, Lopez S., Meân L.J., Meân L.J., Sacks H., Shaw S., Shaw S., Sugden J., Timson‐Katchis M., Tracy K., Weltman D.   +19 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A new age of global security: The 'Ukrainian question' and 'Kosovo precedent' [PDF]

Војно дело, 2017
The research topic of this article is the 'Ukrainian Question' in perspective of 'Kosovo precedent' within the framework of international law, current stream of international relations, contemporary world politics and global security.
Sotirović Vladislav B.
doaj   +1 more source

China`s xinjiang policy: an analysis based on the theory of relative deprivation [PDF]

, 2011
Xinjiang, which is China’s western province that comprised 18 percent of the country’s total land area and heavily populated by non-Han Chinese ethnic minorities, is a region increasingly beset by the problem of confrontation between two very distinct ...
Nur Shahadah Jamil,
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

South Tyrol Issue as a Factor of Interstate Relations between Italy and Austria

Управленческое консультирование, 2020
The research highlights the ethnopolitical conflict within the European Union (using the example of the South Tyrol autonomy). The article states the reasons for the formation of separatist sentiments on the territory of this region, considers in detail ...
M. M. Shumilov, O. I. Shmidt
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source