Results 41 to 50 of about 160,374 (321)

4,6‐O‐Phenylboronic Ester Protection for 1,2‐cis‐α‐Selective Glucosylation

Asian Journal of Organic Chemistry, EarlyView.
The 4,6‐O‐phenylboronic ester protection for 1,2‐cis‐α‐selective glucosylation, previously reported by the Crich group, was revisited and the stereodirecting effect of the cyclic protecting group was unveiled. 4,6‐O‐Phenylboronic ester‐protected glucosyl and 2‐azido‐2‐deoxyglucosyl donors exhibited higher α‐selectivity of the glucosylation than the ...
Yuta Umemura, Taro Udagawa, Naoko Komura, Akihiro Imamura, Hideharu Ishida, Hiromune Ando, Hide‐Nori Tanaka   +6 more
wiley   +1 more source

南瓜籽ACE抑制肽的Plastein反应修饰及分离鉴定Plastein reaction modification of pumpkin seed ACE inhibitory peptide and its isolation and identification

Zhongguo youzhi, 2023
为进一步提升南瓜籽多肽的ACE抑制活性，利用Plastein反应对南瓜籽ACE抑制肽进行修饰，探究底物质量分数、反应温度、反应时间以及3种外源氨基酸添加量对ACE抑制率的影响。采用超滤和Sephadex G-25柱层析等分离修饰产物，并利用LC-MS/MS鉴定肽序列。结果表明：Plastein反应修饰的最佳条件为底物质量分数45%，反应温度20 ℃，反应时间3 h；分别添加亮氨酸、苯丙氨酸或甘氨酸均能显著提升修饰产物的ACE抑制率，其中添加0.5 mmol/g亮氨酸时，修饰产物的ACE抑制率最高 ...
胡田媛1,杨晨1，陈哲2,3，郑竟成1,3，何东平1,3，杨永2,3，雷芬芬1,3 HU Tianyuan1, YANG Chen1, CHEN Zhe2,3, ZHENG Jingcheng1,3, HE Dongping1,3, YANG Yong2,3, LEI Fenfen1,3
doaj   +1 more source

Changes in hemodynamics of pulmonary artery using Flowire in a canine model of acute pulmonary thromboembolism

Animal Models and Experimental Medicine, EarlyView.
This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida, Katsuhiro Matsuura, Akiko Uemura, Ryou Tanaka   +3 more
wiley   +1 more source

Iron-binding fragments from the N-Terminal and C-Terminal regions of human lactoferrin [PDF]

, 1978
Digestion of lactoferrin with pepsin at pH 3.0 gave an iron-binding half-molecule that represents the C-terminal part of the native protein. Tryptic or chymotryptic digestion of 30%/-iron-saturated lactoferrin yielded the N- and C-terminal half ...
Bluard-Deconinck, JM, Evans, RW, Massont, PL, Osinski, PA, Snick, JV, Williams, J   +5 more
core   +1 more source

Phytochemical Investigation and Biological Evaluation of Disynaphia filifolia: A Novel Source of Tremetone in Asteraceae

Chemistry &Biodiversity, EarlyView.
ABSTRACT Chemical investigation of Disynaphia filifolia (Hassl.) R.M. King & H. Rob. (Asteraceae) led to the isolation of eight compounds, with tremetone being the major metabolite recovered. Tremetone has been suggested as the toxic compound in Ageratina altissima and Isocoma pluriflora, two species of the Asteraceae family. Although D.
Yasmin Rodrigues Chierici, Anderson Valdiney Gomes Ramos, Drielli Rhiane Peres Colhado Areas, Alana Carla Battistella, Solange Maria Cottica, Tatiana Shioji Tiuman, Helena Mannochio‐Russo, Ana Lucia Tasca Gois Ruiz, Mary Ann Foglio, Marta Regina Barrotto do Carmo, Maria Helena Sarragiotto, Debora Cristina Baldoqui   +11 more
wiley   +1 more source

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Detection of DNA-RNA hybrids in vivo [PDF]

, 2017
DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they may be an important source of genome instability, a hallmark of cancer and genetic diseases.
Aguilera López, Andrés, Barroso Ceballos, Sonia Inés, García Rubio, María Luisa   +2 more
core   +1 more source

Liquid-gel chromatography on lipophilic-hydrophobic Sephadex derivatives

Journal of Lipid Research, 1970
Hydrophobic long-chain alkyl ethers of Sephadex have been synthesized and tested for use in liquid chromatography. With columns prepared in such polar solvents as methanol, reversed-phase systems are obtained where compounds separate in order of ...
J. Ellingboe, E. Nyström, J. Sjövall
doaj  

Cytotoxic Activity of Opopanax hispidus (Friv.) Griseb.: Characterization of a New Chalcone‐type Compound

Chemistry &Biodiversity, EarlyView.
ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban, İpek Süntar, Perihan Gürbüz, Esra Emerce, Osman Tugay, Şengül Dilem Doğan, Beyza Hamur, Ahmet Ceyhan Gören   +7 more
wiley   +1 more source

Exploring separation patterns and mechanisms of proanthocyanidins in grape seeds and pomace with diverse molecular weights, compositions, and structures

Food Chemistry: X, 2023
The function of proanthocyanidins (PAs) relies on their structure and requires high-purity PAs. Though Sephadex LH-20 gel permeation chromatography (GPC) is expected to separate PAs based on structure, its usage rules and mechanisms remain unclear.
Xiaoyi Chen, Hong Song, Shubo Zhou, Chunlong Yuan, Junjun Li   +4 more
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