Results 51 to 60 of about 553,208 (143)
Brain and Behavior, Volume 15, Issue 7, July 2025.Mendelian randomization (MR) analysis was applied to elucidate the causal relationship between immune cell proteins and PD. Our study reveals a possible causal effect of immune cell proteins on the risk of PD and provides new ideas for the prevention and management of PD through immune cell proteins.
Haining Li +7 more
wiley +1 more source
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.ABSTRACT Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) plays an essential role in the maintenance of vascular homeostasis and the prevention of vascular inflammation. There are a myriad of mechanisms that regulate the activity of the enzyme that may prove to represent interesting therapeutic opportunities.
Riham Rafea +2 more
wiley +1 more source
Helicobacter, Volume 30, Issue 2, March/April 2025.ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong +5 more
wiley +1 more source
Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase [PDF]
, 2014 Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism.
Vladimir Mishin +8 more
core
Ibnosina Journal of Medicine and Biomedical Sciences, 2020 Dopa-responsive dystonia (DRD) encompasses clinically and genetically heterogeneous disorders that typically manifest as limb-onset, diurnally fluctuating dystonia and exhibit a robust and sustained response levodopa treatment. GCH1 gene mutations are the most frequent cause of DRD. Mutations in the TH or SPR gene less often cause this condition.
Samira Etarhuni +3 more
openaire +1 more source
, 2019 Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Olivia Jackson (3835966) +7 more
core +3 more sources
Understanding Parkinson disease in Spain: Genetic and clinical insights
European Journal of Neurology, Volume 32, Issue 1, January 2025.Abstract Background and purpose Parkinson disease (PD) is a complex and heterogeneous neurodegenerative disorder with a broad spectrum of clinical manifestations, determined by a complex interplay of environmental and genetic factors. This study aimed to investigate genetic variants associated with PD and assess their impact on the disease phenotype ...
Pilar Gómez‐Garre +15 more
wiley +1 more source
Cloning And Ontogenic Expression Of Sepiapterin Reductase Mrna In Zebrafish Embryo : Possible Role In Pteridine Biosynthesis [QL767. K95 2008 f rb]. [PDF]
, 2008 Sepiapterin reductase (SR, EC1.1.1.153) memangkinkan langkah terakhir di dalam laluan biosintesis de novo bagi tetrahidrobiopterin (BH4), yang mana merupakan kofaktor sangat penting untuk penghasilan pteridin di dalam kromatofor teleost.
Kuah, Meng Kiat
core +1 more source
IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou +3 more
wiley +1 more source
Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells
, 2013 In the lung, chemical redox cycling generates highly toxic reactive oxygen species that can cause alveolar inflammation and damage to the epithelium, as well as fibrosis.
Yang, Shaojun +6 more
core +1 more source