Results 61 to 70 of about 553,208 (143)

Enzymatic Isomerization of Sepiapterin to 6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin

, 1989
6-1'-Hydroxy-2' -oxopropyl 7,8-dihydropterin, which has been believed to be too labile to actually exist, was produced from sepiapterin (6-lactoyl 7,8-dihydropterin).
Sueoka Terumi, Katoh Setsuko
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Tissue Expression Of The 6-Pyruvoyi Tetrahydropterin Synthase Gene In Adult Zebrafish,Danio Rerio. [PDF]

, 2004
Teleost is one of the poikilotherms that can display different kind of colours on their body. This is due to the presence of different types of chromatophores, a group of pigment containing cells that is distributed in the epidermal layer of skin and ...
Tengku Muhammad, Tengku Sifzizul, Chan, Woon Khiong, Kuah, Meng Kiat, Chong, Alexander   +3 more
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Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population

, 2015
Jiawu Fu,1,* Guoda Ma,1,* Hui Mai,1,* Xudong Luo,2 Jingwen Yin,2 Qing Chen,2 Zhixiong Lin,2 Hua Tao,1 You Li,1 Lili Cui,1 Zheng Li,3 Juda Lin,2 Bin Zhao,1 Keshen Li1 1Institute of Neurology, Affiliated Hospital of Guangdong Medical University ...
Ma GD, Chen Q, Lin JD, Zhao B, Lin ZX, Tao H, Fu JW, Luo XD, Li Y, Li Z, Li KS, Yin JW, Mai H, Cui LL   +13 more
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Mthfrdeficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1

, 2011
Hyperhomocysteinemia (HHcy) has been shown to induce endothelial dysfunction in part as a result of enhanced oxidative stress. Function and survival of endothelial progenitor cells (EPCs, defined as sca1+c-kit+flk-1+bone marrow-derived cells), which ...
Catherine A. Lemarié, Layla Shbat, Marie-Eve Deschênes, Ernesto L. Schiffrin, Mark D. Blostein, Pierre Paradis, Orlando J. Angulo, Chiara Marchesi   +7 more
core   +1 more source

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH₄ Pathway [PDF]

, 2019
Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Armitage, R, Islam, B, Moore, BJR, McHugh, PC, Haider, S, Ward, S, Blackburn, J, Jackson, O   +7 more
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Sepiapterin reductase inhibitors

Inhibitors of sepiapterin reductase and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.AVP-R-TTOLIPAlternative title(s) : (de) Heteroarylderivate ...
Gorska, Katarzyna Irena, Johnsson, Kai Peter, Meniconi, Mirco, Bromidge, Steven Mark, Kerry, Mark, Peng, Hairuo, Saiah, Eddine, Mccall, John Michael, Atton, Holly Victoria, Kotey, Adrian Kotei, Monck, Nathaniel J, Avery, Craig, Tebbe, Mark Joseph, Ridgill, Mark Peter, Tye, Heather   +14 more
core  

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

, 2019
Tetrahydrobiopterin (BH4) is a cofactor in the production of various signaling molecules including nitric oxide, dopamine, adrenaline, and noradrenaline.
Jackson, Olivia, Mchugh, Patrick C., Islam, Barira, Armitage, Rebecca, Blackburn, Jack, Haider, Shozeb, Ward, Sean, Moore, Benjamin J. R.   +7 more
core   +1 more source

Control of pteridine biosynthesis in the natural killer-like cell line YT.

, 1991
The natural killer-like cell line YT constitutively expresses GTP-cyclohydrolase activity whereas 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase are absent.
Yodoi, J., Schwulera, U., Schott, K., Ziegler, I.   +3 more
core   +1 more source

Regulation of tetrahydrobiopterin synthesis during lectin stimulation of human peripheral blood lymphocytes

, 1989
Lectin stimulation of human T lymphocytes causes a 7-fold increase in the specific activities of GTP-cyclohydrolase and a 4-fold increase in the specific activities of sepiapterin reductase.
Adelbert Bacher, Kerler, F., Ziegler, I., Bruno Schwarzkopf, Schwarzkopf, B., Irmgard Ziegler, Bacher, A., Franz Kerler   +7 more
core   +1 more source

c.207C>G mutation in sepiapterin reductase causes autosomal dominant dopa-responsive dystonia

, 2017
Objective:To elucidate the genetic cause of an Egyptian family with dopa-responsive dystonia (DRD), a childhood-onset dystonia, responding therapeutically to levodopa, which is caused by mutations in various genes.Methods:Rare variants in all coding ...
Ulrich Müller, Ali S. Shalash, Thomas Opladen, Mohamed Salama, Günther Deuschl, Franziska Hopfner, Gregor Kuhlenbäumer, Andre Franke, Britt-Sabina Petersen, Thomas W. Rösler, Stefanie H. Müller, Günter U. Höglinger   +11 more
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