Results 131 to 140 of about 1,046,938 (380)

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy [PDF]

, 2012
Background: In macrophages Toll-like receptor 4 (TLR4) is activated in response to lipopolysaccharide (LPS) and induces proinflammatory cytokine expression. Therefore, mechanisms terminating proinflammatory gene expression are important.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Heide, Hermann, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura   +6 more
core   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Kinetic characterization of selective peroxisome-proliferator-activated receptor gamma modulators in vitro [PDF]

, 2012
Background: The ligand-activated transcription factor, peroxisome-proliferator-activated receptor gamma (PPARγ), has been shown to play an essential role in immunosuppression during sepsis.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura, Parnham, Michael J.   +6 more
core   +1 more source

Therapy of sepsis [PDF]

Clinical Microbiology and Infection, 1997
The term 'sepsis' is often used synonymously with 'infection' or 'bacteremia'. Additional definitions, e.g. 'systemic inflammatory response syndrome', have been proposed. These terms have been employed to establish entry criteria for clinical trials of antibiotic therapy and adjunctive therapies. It may be appropriate to utilize these descriptions when
openaire   +3 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Electrical Monitoring of Vibrio vulnificus–Host Cell Membrane Interactions in Simple and Complex Matrices

Advanced Materials Interfaces, EarlyView.
Supported lipid bilayers coupled with multielectrode array devices offer significant promise for pathogen–host cell membrane interaction studies. This work demonstrates, for the first time, the compatibility of this platform with biological fluids, in this case whole human blood, essential for any future point‐of‐care applications; as well as its ...
Alexandra Wheeler, Zixuan Lu, Jeremy Treiber, Alberto Salleo, Róisín M. Owens   +4 more
wiley   +1 more source

Effects of different dosages/frequency of Xuebijing injection (a Chinese patent) for sepsis: a network meta-analysis of randomized controlled trials

Frontiers in Medicine
ObjectiveXuebijing injection (XBJ) has been widely recognized in the treatment of sepsis, however, inadequate information regarding XBJ's optimal dosage and frequency suffice.
Guangyan Liu, Guangyan Liu, Xueping Qu, Xueping Qu, Ruowen Jiang, Ruowen Jiang, Yongxing Wu, Yongxing Wu, Zan Qin, Zan Qin, Hui Zhang, Hui Zhang, Ruze Ma, Ruze Ma, Jiawei Xue, Jiawei Xue, Junwu Wang, Junwu Wang, Xueqin Xu, Xueqin Xu, Chenxi Yan, Chenxi Yan, Xiaodan Wei, Xiaodan Wei, Litao Guo, Litao Guo   +25 more
doaj   +1 more source

An Anti‐Myd88 Peptide Synergistically Enhances the Anti‐Inflammatory Effects of Extracellular Vesicles from Naïve Umbilical Cord MSC or HEK293F CD24 Overexpressing Cells

Advanced Materials Interfaces, EarlyView.
This study confirms that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) or HEK293F cells overexpressing CD24 have anti‐inflammatory effects in macrophages and monocytes. Further loading either of these EVs with an anti‐Myd88 peptide synergistically enhanced the anti‐inflammatory effects of the EVs.
Burçin İrem Abas, Markus Bergqvist, Lijuan Yu, Yi Wang, Mario Gimona, Kyong‐su Park, Jan Lötvall   +6 more
wiley   +1 more source

Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma

Molecular Medicine, 2019
Background The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their peripheral immune cells.
Amol Kolte, Rainer König
doaj   +1 more source

The Gynæcological Aspect of Focal Sepsis [PDF]

, 1940
Aleck Bourne
openalex   +1 more source