Results 131 to 140 of about 870,778 (357)
Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis [PDF]
, 2022 Juliette Gauthier, Murielle Grégoire, Florian Reizine, Mathieu Lesouhaitier, Yoni Desvois, Gevorg Ghukasyan, Caroline Moreau, Patricia Amé-Thomas, Karin Tarte, Jean‐Marc Tadié, Céline Delaloy +10 moreopenalex +1 more sourcePRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma
Advanced Science, EarlyView.Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen +12 morewiley +1 more sourcePlasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis
Frontiers in ImmunologyBackgroundPolymeric immunoglobulin receptors (pIgR) may enhance mucosal immunity or worsen an infection through transcytosis of polymeric immunoglobulins or infectious pathogens.Shuaiwei Wang, Hao Fu, Hao Fu, Xiaoqing Li, Xiaoqing Li, Hongrui Xu, Yu Bai, Wenjun Jiang, Xiaozhe Cheng, Na Chen, Na Chen, Yijie Zhang, Yijie Zhang, Wei Li +13 moredoaj +1 more sourceThe role of IL-6 for predicting neonatal sepsis: A systematic review and meta-analysis [PDF]
, 2011 Objective: Neonatal sepsis (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS.Ahani, A., Keshtkar, A., Mirfazeli, A., Roshandel, G., Shahkar, L. +4 morecore +1 more sourceSepsis in Brazilian emergency departments: a prospective multicenter observational study
, 2023 Flávia Ribeiro Machado, Alexandre B. Cavalcanti, Maria Aparecida Braga, Fernando S. Tallo, Aline Siqueira Bossa, Juliana Lubarino Diniz de Souza, Josiane F. Ferreira, Felipe Dal‐Pizzol, Mariana Barbosa Monteiro, Derek C. Angus, Thiago Lisboa, Luciano César Pontes Azevedo, Sandro Alves, Cinda Velasco, Glenda F. Sanches, L. N. Azevedo, Evaristo Bianchini Sobrinho, Adriana O.L. Veríssimo, A. G. Macêdo, André Pinz Borges, Fernanda Silva Colombari, Ana Mônica Quinta Barbosa Habitante, G. S. Oliveira, R. M. Oliveira Filho, N. M. Gambero, Leonard Campos Avellar Machado, J. A. L. Albuquerque, Sanal Fernandes, B. A. M. P. Bessen, Eliana V. N. Martins, M. R. da Silva, Eric José Oliveira de Paula, Maria Márcia Caetano Silva, André Ferreira Pereira, P. A. Quesado, Gisselly Mendonça Fernandes, W. Ayrão, Narhayanne Kondratievans, Illoma Rossany Lima Leite, Plotnikov Sa, Eduardo Alexandre de Oliveira, Ivanir Freitas, Diogo Borges Pedroso, Aurenívia Bonifácio, S. A. Santos, M. B. do Amaral, A Alves, S H C Carvalho, Juliana Cristina Fernandes, Cristina Duarte, G.R. Fonseca, L. G. Almeida, L. C. de Oliveira, R. N. Oliveira, M. Damos, Renato Souza, Vanessa Santana dos Santos, André Rodrigues Durães, Yaser Bitar, F. Liberali, Carolina Assaf Branco, Luiz Fernando Varela, Katia Aparecida Pessoa Conde, Erica Almeida Carvalho Peixoto, Renata Bonini Pardo, L. Delgatto, Chris Jacob, Antônio Augusto Moura da Sílva, L. M. B. Vinãs, Karina Daniela Araujo Gomes Coqueti, M. C. G. Ribeiro, G. B. A. Faria, D. A. S. F. da Silva, Juana Souto Jardim, Alberto Queiróz Farias, A. P. Amorin, Z. E. Sakamoto, V. H. C. Barros, Antônio Luíz Martins Maia Filho, D. P. de Oliveira, Rita Miranda Coessens Guimarães, Luiz F. Pires, Miguel Angel Sicolo, B. B. K. Boettger, Fabíola Attié de Castro, Jun Yamano, A. R. Da Silva, Cristian Dornelles, González-Palomares Alba, A. P. Correa, N. de Alcantara, A. Martins, N. B. Gouveia, Rogerio Luz Coelho Neto, Alexandre Toledo Maciel, Camylle Santos Matos, E. G. L. Guadalupe, Maria Fernanda Bádue Pereira, R. Rabe, Teresa Smith +99 moreopenalex +2 more sourcesA Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction
Advanced Science, EarlyView.Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao +10 morewiley +1 more sourceTemporary bilateral clamping of renal arteries induces ischemia–reperfusion: A new pig model of acute kidney injury using total intravenous anesthesia
Physiological ReportsIschemia‐reperfusion (IR) is a leading cause of acute kidney injury (AKI), and pigs are commonly used in preclinical AKI models. However, existing models often vary in the methods used to induce ischemia, and the resulting AKI tends to be mild‐to ...Axel Guilpin, Mathieu Magnin, Axel Aigle, Jean‐Yves Ayoub, Timothée Schuhler, Romain Lac, Thierry Marchal, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier +9 moredoaj +1 more source
