Results 281 to 290 of about 815,905 (331)

Manganese Neurotoxicity and Familial Disorders of Manganese Transport

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley   +1 more source

MitoQ alleviates mitochondria damage in sepsis-acute lung injury in a citrate synthase dependent manner. [PDF]

Inflamm Res
Sun J, Jin S, Wang Z.
europepmc   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

Effects of Acute Abdomen III on Sepsis-Induced Intestinal Damage in a Rat Model. [PDF]

J Microbiol Biotechnol
Wang L, Hu J, Hu F, Chen Y, Fang M, Ye Y.   +5 more
europepmc   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, EarlyView.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin, Ramya Mahadevan, Gauri G. Rao, Alexandre P. Zavascki, Ana Maria Sandri, Andrea Kwa, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P.Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Anthony W. Purcell, Roger L. Nation, Jason M. Pogue, Jian Li, Keith S. Kaye   +19 more
wiley   +1 more source

Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. [PDF]

Sci Rep
Park C, Ryu T, Mohamed-Hinds R, Kim K, Kim JH, Zou L, Williams B, Na CH, Chao W.   +8 more
europepmc   +1 more source

Hierarchical clustering of clinical and flow cytometry parameters is associated with deterioration in patients with community‐acquired pneumonia in the emergency department: A preliminary study

Cytometry Part B: Clinical Cytometry, EarlyView.
ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon, Robin Jeannet, Thomas Daix, Guillaume Monneret, Jean Feuillard   +4 more
wiley   +1 more source

Significance of the Hematological Scoring System (HSS) in the Early Diagnosis of Neonatal Sepsis in a Tertiary Care Center. [PDF]

Cureus
Kushwaha R, Singh LP, Yadav J, Verma D.
europepmc   +1 more source

Fate of wastewater nitrogen upon injection into a coastal saline groundwater system, Florida Keys, USA

The Depositional Record, EarlyView.
Despite advanced wastewater treatment, dilution by rainwater and mixing, and microbial modification, nitrogen nutrients derived from shallowly injected wastewater are detected in nearshore waters in the Florida Keys. Abstract Injection of treated wastewater into the shallow subsurface on islands and along coastlines is a common practice in areas like ...
Miquela Ingalls, Lee R. Kump, Emily Stoller, Kate Meyers   +3 more
wiley   +1 more source