Results 161 to 170 of about 10,190,973 (293)

Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. [PDF]

CPT Pharmacometrics Syst Pharmacol
Olivo LB, de Lemos JLS, Rodrigues VJ, de Araújo BV.   +3 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Agreement of Multimodal Large Language Models and Novice Readers With Expert-Based Radiographic Scoring of Presumptive Septic Carpal Arthritis in Calves. [PDF]

Vet Radiol Ultrasound
Bedir AG, Modoğlu E, Kartal T, Kibar B, Gökhan Şenocak M, Orhun ÖT, Turgut F, Ersöz U, Kocaman Y, Akçora Y, Okur S, Yanmaz LE.   +11 more
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Interpretable Machine Learning Model for Predicting Sepsis and Septic Shock Among Patients with Documented Fever at Emergency Department Triage Using Patients' Historical Data. [PDF]

J Med Syst
Maeng SJ, Lee YR, Lee SU, Yu JY, Choi JW, Lee G, Park JE, Shin TG, Hwang SY, Yoon H, Cha WC, Kim T, Kim M, Chang H, Heo S.   +14 more
europepmc   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Taming Macrophage Inflammasomes at the Sepsis-Lung Injury Interface: Lessons from Bats. [PDF]

Biomedicines
Chen S, Luo J, Zhang P, Gu S, Shen Y, Lin Z, Wu Y, Zhang C, Tang Z.   +8 more
europepmc   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Neutrophil Extracellular Traps (NETs), Immunothrombosis and the Microvascular Siege in Sepsis-ARDS. [PDF]

Pulm Circ
El-Sehrawy AAMA, Mansurov D, Baig MR, Abdelrahim IM, Bainsal N, Bansal P, Abdullah SS, Khaleel ZT, Jabir MS, Smerat A.   +9 more
europepmc   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source