Results 141 to 150 of about 538,518 (347)

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

Animal models of benign airway stenosis: Advances in construction techniques, evaluation systems, and perspectives

Animal Models and Experimental Medicine, EarlyView.
Currently, the animals commonly used to establish animal models of benign airway stenosis (BAS) include mice, rats, pigs, dogs, rabbits, and ferrets. The establishment methods involve one or a combination of two methods such as mechanical injury, tracheal cautery, cuff overpressure intubation, laser injury, and endoscopic silver nitrate cauterization ...
Wusheng Zhang, Yilin Chen, Chengcheng Yang, Yuchao Dong, Haidong Huang, Hui Shi, Chong Bai   +6 more
wiley   +1 more source

Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See

Clinical, Cosmetic and Investigational Dermatology, 2021
Ji-Cong Jiang,1,* Qin Xu,2,* Shan Fang,3 Yu Gao,1 Wan-Wan Jin1 1Department of Dermatology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, People’s Republic of ...
Jiang JC, Xu Q, Fang S, Gao Y, Jin WW
doaj  

Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4+ Effector Memory Cells

Arthritis &Rheumatology, EarlyView.
Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Methods In an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at ...
Hanna Graßhoff, Sara Comdühr, Henry Nording, Jacob von Esebeck, Philine Letz, Miriam Prohaczka, Handan Gedik, Henner Zirpel, Elisabeth Spallek, Linh Ha‐Wissel, El‐Baraa Adjailia, Sabrina Arnold, Konstantinos Fourlakis, Sebastian Klapa, Ingo Eitel, Oliver J. Müller, Jens Y. Humrich, Gabriela Riemekasten, Diamant Thaçi, Peter Lamprecht   +19 more
wiley   +1 more source

Intraoperative tourniquet-induced hyperthermia in a pediatric patient: a forgotten association -a case report- [PDF]

Korean Journal of Anesthesiology
Background The intraoperative use of tourniquets is associated with several complications, including hyperthermia. We present the first documented case of tourniquet-induced hyperthermia in a pediatric patient at our institution. Case A 5-year-old female
Tarek Tageldin, Muhammad Jaffar Khan, Temur Baykuziyev, Haitham Ahmed   +3 more
doaj   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis with Polyangiitis: Findings from a Large European Cohort

Arthritis &Rheumatology, Accepted Article.
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common.
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, The French Vasculitis Study Group and the EGPA European Study Group   +35 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials

Frontiers in Antibiotics
Tuberculosis drug trials are primarily designed to identify antibiotic regimens with the strongest potency to kill Mycobacterium tuberculosis. However, microbiologic cure is not synonymous with improved health and recovery. Beyond antimicrobial efficacy,
Andrew R. DiNardo, Andrew R. DiNardo, Wilbert Sabiiti, Stephen H. Gillespie, Sophia B. Georghiou, Norbert Heinrich, Norbert Heinrich, Norbert Hittel, Sami Taghlabi, Danna Carrero Longlax, Mikashmi Kohli, Ursula Panzner, Ursula Panzner, Collins Musia, Christoph Lange, Christoph Lange, Christoph Lange, Christoph Lange, Anca Vasiliu, Anca Vasiliu, Anca Vasiliu, Rob J. W. Arts, Anna M. Mandalakas, Anna M. Mandalakas, Anna M. Mandalakas, Morten Ruhwald, Lieven J. Stuyver, Reinout van Crevel, Reinout van Crevel   +28 more
doaj   +1 more source

3D bioprinting in oral and craniomaxillofacial tissue regeneration: Progress, challenges, and future directions

BMEMat, EarlyView.
This paper summarized the application of 3D bioprinting in the regeneration of various tissues in the oral and craniomaxillofacial fields, including the required biomaterials and printing techniques. Abstract Oral and craniomaxillofacial tissues are essential for maintaining oral functions, including respiration, mastication, swallowing, and speech ...
Huilu Zhan, Haohao Ni, Xingge Yu, Mazaher Gholipourmalekabadi, Tianqi Wang, Kaili Lin, Jinsong Pan, Changyong Yuan   +7 more
wiley   +1 more source

Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

Frontiers in Cellular and Infection Microbiology
Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history.
Juan S. Izquierdo-Condoy, Jorge Vásconez-Gonzáles, Estefanía Morales-Lapo, Andrea Tello-De-la-Torre, Patricio Naranjo-Lara, Ricardo Fernández, Marlon R. Hidalgo, Adriana Escobar, Vanessa Herrera Yépez, Ana María Díaz, Carlos Oliva, Esteban Ortiz-Prado   +11 more
doaj   +1 more source