Results 131 to 140 of about 4,228,228 (319)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Communications of the ACM, 2011 Probabilistic models of sequences play a central role in most machine translation, automated speech recognition, lossless compression, spell-checking, and gene identification applications to name but a few. Unfortunately, real-world sequence data often exhibit long range dependencies which can only be captured by computationally challenging, complex ...
Wood, Frank +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Quantifying the Discord: Order Discrepancies in Message Sequence Charts
, 2007 Message Sequence Charts (MSCs) and High-level Message Sequence Charts (HMSC) are formalisms used to describe scenarios of message passing protocols. We propose using Allen's logic to study the temporal order of the messages. We introduce the concept of {\
Genest, Blaise +7 more
core
, 2022 Sequence-to-Sequence Learning-Based Conversion of Pseudo-Code to Source Code Using Neural Translation ...
KM Hossen (18855346) +5 more
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A methodology for the concurrent design of products and their assembly sequence [PDF]
, 1999 This thesis reports on the development of a Two-Tier methodology that provides support for assembly sequence construction, validation and evaluation in parallel with the design.
Barnes, C. J.
core
Sequence ‘minimization’: exploring the sequence landscape with simplified sequences
Current Opinion in Biotechnology, 1995 The challenges of protein engineering arise, in part, from the enormous number of possible sequences and the almost unimaginably small fraction of such sequences that can be studied experimentally or computationally. Fortunately, not all possibilities need to be considered because many different sequences can adopt the same structure.
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source