Results 61 to 70 of about 4,228,228 (319)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
twichma/Sequence-and-pattern-detection: Sequence and pattern detection code
, 2022 Code for sequence and pattern ...
twichma
core +1 more source
High-quality metagenome assembly from nanopore reads with nanoMDBG
Nature CommunicationsThird-generation long-read sequencing technologies, significantly improve metagenome assemblies. Highly accurate PacBio HiFi reads can yield hundreds of near-complete metagenome-assembled genomes (MAGs) from a single sample. Recently, the accuracy of the
Gaëtan Benoit +6 more
doaj +1 more source
Clinical Epidemiology and Global HealthBackground: Tuberculosis (TB) is one of the leading causes of death worldwide. However, an accurate diagnosis contributes to timely treatment, reducing its adverse consequences.
Miguel Hueda-Zavaleta +9 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang +7 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Characterizing Communication Channel Deadlocks in Sequence Diagrams
, 2008 UML sequence diagrams (SDs) are a mainstay of requirements specifications for communication protocols. Mauw and Reniers' algebraic (MRA) semantics formally specifies a behaviour for these SDs that guarantees deadlock free processes.
Mitchell, Bill, B. Mitchell
core +1 more source
Assessing Incrementality in Sequence-to-Sequence Models [PDF]
Proceedings of the 4th Workshop on Representation Learning for NLP (RepL4NLP-2019), 2019 Since their inception, encoder-decoder models have successfully been applied to a wide array of problems in computational linguistics. The most recent successes are predominantly due to the use of different variations of attention mechanisms, but their cognitive plausibility is questionable.
Ulmer, D., Hupkes, D., Bruni, E.
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Multiple sequence alignment with the Divide-and-Conquer method.
, 1998 Stoye J. Multiple sequence alignment with the Divide-and-Conquer method. Gene. 1998;211(2):GC45-GC56.An improved algorithm for the simultaneous alignment of multiple protein and nucleic acid sequences, the Divide-and-Conquer Alignment procedure (DCA), is
Jens Stoye +1 more
core +1 more source