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Recent Advances in DNA Sequence Analysi
CRC Critical Reviews in Biochemistry, 1975(1975). Recent Advances in DNA Sequence Analysi. CRC Critical Reviews in Biochemistry: Vol. 2, No. 4, pp. 455-512.
Ray Wu +3 more
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Statistical Analysis of DNA Sequences
JNCI Journal of the National Cancer Institute, 1988Developments in the statistical analysis of DNA sequence data since 1984 are reviewed. Mathematical methods employing dynamic programming or incorporating Markov chain theory have been developed to search sequences for regions of similarity and to align sequences.
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Computer support of DNA sequence analysis
Computer Programs in Biomedicine, 1981The paper describes a package of APL-programs suited for the management and the analysis of DNA sequence data. Most of the application programs are related to experimental work in a DNA sequencing laboratory: Search for overlapping DNA fragments to construct complete DNA sequences; search for restriction sites; computing fragment patterns when cutting ...
G, Osterburg, R, Sommer
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Quantitative analysis of DNA-sequencing electrophoresis
Genetic Analysis: Biomolecular Engineering, 1992At the heart of the DNA-sequencing process is a remarkably selective electrophoretic separation of up to 1000 oligonucleotide fragments, each differing in size by only a single nucleotide unit. A quantitative analysis of this separation is performed in terms of both selectivity and efficiency.
P D, Grossman, S, Menchen, D, Hershey
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Video analysis of DNA sequence homologs
Analytical Chemistry, 1992A method for the rapid quantitative analysis of dot blot assays is presented. A video camera, an NTSC compatible frame grabber board, and an AT personal computer are used to read photographic exposures of the assay plate. Image processing and image analysis techniques are used to calculate the orientation of the dot raster and then to compensate for ...
M, Ludwig, R J, Hartzman
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Analysis of rat repetitive DNA sequences
Biochemistry, 1978Parameters of repetitive sequence organization have been measured in the rat genome. Experiments using melting, hydroxylapatite binding, and single strand specific nuclease digestion have been used to measure the number, length, and arrangement of repeated DNA sequences.
W R, Pearson, J R, Wu, J, Bonner
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DNA sequence analysis and the computer
Biochemical Society Transactions, 1984Analysis of DNA sequences has greatly aided our understanding of molecular biology and genetics. Nucleotide sequences have provided a wealth of information about gene structure and function. In addition to revealing the primary structure of genes, sequencing has uncovered the phenomena of overlapping genes, segmented genes, pseudogenes and a different ...
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A Markov analysis of DNA sequences
Journal of Theoretical Biology, 1983We present a model by which we look at the DNA sequence as a Markov process. It has been suggested by several workers that some basic biological or chemical features of nucleic acids stand behind the frequencies of dinucleotides (doublets) in these chains.
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Mixed Model Analysis of DNA Sequence Evolution
Biometrics, 1995Nucleotides in a DNA sequence may be changing at different rates, because they are located in different structural and functional regions of the gene, and are thus subject to different mutational pressures or selective restrictions. Knowledge of substitution rates at specific sites is important for understanding the forces and mechanisms that have ...
Yang, Ziheng, Wang, Tianlin
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2009
In this chapter we introduce some of the elementary concepts for analyzing DNA sequences in terms of “words” of length 1 (bases), 2 (base pairs), 3 (triplets, such as codons), restriction sites, etc. The analysis uses some of the basic probability concepts that we have worked with in the previous chapter.
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In this chapter we introduce some of the elementary concepts for analyzing DNA sequences in terms of “words” of length 1 (bases), 2 (base pairs), 3 (triplets, such as codons), restriction sites, etc. The analysis uses some of the basic probability concepts that we have worked with in the previous chapter.
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