Results 91 to 100 of about 2,818,524 (302)

Improved contact prediction in proteins: Using pseudolikelihoods to infer Potts models

, 2013
Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional (3D) structure hence leaves an echo of correlations in the evolutionary record.
Aurell, Erik, Ekeberg, Magnus, Lan, Yueheng, Lövkvist, Cecilia, Weigt, Martin   +4 more
core   +1 more source

Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis. [PDF]

, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Cabezas-Cruz, Alejandro, de la Fuente, José, Estrada-Peña, Agustín, Ferrolho, Joana, Grubhoffer, Libor, Kenneil, Rachel, Kocan, Katherine M., Lis, Katarzyna, Passos, Lygia M. F., Pohl, Anna E., Ribeiro, Mucio F. B., Shkap, Varda, Tonk, Miray, Valdés, James J., Zweygarth, Erich   +14 more
core   +6 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A primary sequence analysis of the ARGONAUTE protein family in plants.

Frontiers in Plant Science, 2016
Small RNA (sRNA)-mediated gene silencing represents a conserved regulatory mechanism controlling a wide diversity of developmental processes through interactions of sRNAs with proteins of the ARGONAUTE (AGO) family.
Daniel Rodriguez-Leal, Amanda Castillo-Cobián, Isaac Rodriguez-Arévalo, Jean-Philippe Vielle-Calzada   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Bioinformatics Analysis of BMP15 Gene and Bone Morphological Protein-15 Sequence [PDF]

Journal of Applied Sciences and Nanotechnology
This study characterized the physicochemical properties and predicted the structure, function, and protein-protein interactions of bone morphogenetic protein 15 (BMP15) using bioinformatics tools.
Maryam Kamel, Ali Issa, Rand Sattar, Rusul Sami, Yasser Hussein, Doaa El-Sayed, Adawiya Haider, Bilal Jasim   +7 more
doaj   +1 more source

Folding and Misfolding of Designed Heteropolymer Chains with Mutations

, 1997
We study the impact of mutations (changes in amino acid sequence) on the thermodynamics of simple protein-like heteropolymers consisting of N monomers, representing the amino acid sequence. The sequence is designed to fold into its native conformation on
Broglia, R. A., Roman, H. E., Shakhnovich, E., Tiana, G., Vigezzi, E.   +4 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Updating the Vibrio Clades Defined by Multilocus Sequence Phylogeny: Proposal of Eight New Clades, and the Description of Vibrio tritonius sp. nov.

Frontiers in Microbiology, 2013
To date 142 species have been described in the Vibrionaceae family of bacteria, classified into seven genera; Aliivibrio, Echinomonas, Enterovibrio, Grimontia, Photobacterium, Salinivibrio and Vibrio.
Tomoo eSawabe, Yoshitoshi eOgura, Yuta eMatsumura, Feng eGao, AKM Rohul Amin, Sayaka eMino, Satoshi eNakagawa, Toko eSawabe, Ramesh eKumar, Yohei eFukui, Masataka eSatomi, Ryoji eMatsushima, Fabiano L. Thompson, Bruno eGomez-Gil, Richard eChristen, Richard eChristen, Fumito eMaruyama, Ken eKurokawa, Testuya eHayashi   +18 more
doaj   +1 more source