Results 91 to 100 of about 2,800,473 (300)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A primary sequence analysis of the ARGONAUTE protein family in plants.

Frontiers in Plant Science, 2016
Small RNA (sRNA)-mediated gene silencing represents a conserved regulatory mechanism controlling a wide diversity of developmental processes through interactions of sRNAs with proteins of the ARGONAUTE (AGO) family.
Daniel Rodriguez-Leal, Amanda Castillo-Cobián, Isaac Rodriguez-Arévalo, Jean-Philippe Vielle-Calzada   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Bioinformatic analysis of THAP9 transposase homolog: conserved regions, novel motifs

Current Research in Structural Biology
THAP9 is a transposable element-derived gene that encodes the THAP9 protein, which is homologous to the Drosophila P-element transposase (DmTNP) and can cut and paste DNA. However, the exact functional role of THAP9 is unknown. Here, we perform structure
Richa Rashmi, Chandan Nandi, Sharmistha Majumdar   +2 more
doaj   +1 more source

Improved contact prediction in proteins: Using pseudolikelihoods to infer Potts models

, 2013
Spatially proximate amino acids in a protein tend to coevolve. A protein's three-dimensional (3D) structure hence leaves an echo of correlations in the evolutionary record.
Aurell, Erik, Ekeberg, Magnus, Lan, Yueheng, Lövkvist, Cecilia, Weigt, Martin   +4 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

In silico study of Bacillus spB201 amylase through protein sequence inspection

Journal of the Arab Society for Medical Research
Background/aim Bioinformatics is the automatic processing of biological information, and it is a helpful tool to study the structure-function relationship of various proteins.
Sameh Ben Mabrouk, Bouthaina Ben Hadj Hmida, Ikram Boukthir, Slim Cherif   +3 more
doaj   +1 more source

Bioinformatics Analysis of BMP15 Gene and Bone Morphological Protein-15 Sequence [PDF]

Journal of Applied Sciences and Nanotechnology
This study characterized the physicochemical properties and predicted the structure, function, and protein-protein interactions of bone morphogenetic protein 15 (BMP15) using bioinformatics tools.
Maryam Kamel, Ali Issa, Rand Sattar, Rusul Sami, Yasser Hussein, Doaa El-Sayed, Adawiya Haider, Bilal Jasim   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Updating the Vibrio Clades Defined by Multilocus Sequence Phylogeny: Proposal of Eight New Clades, and the Description of Vibrio tritonius sp. nov.

Frontiers in Microbiology, 2013
To date 142 species have been described in the Vibrionaceae family of bacteria, classified into seven genera; Aliivibrio, Echinomonas, Enterovibrio, Grimontia, Photobacterium, Salinivibrio and Vibrio.
Tomoo eSawabe, Yoshitoshi eOgura, Yuta eMatsumura, Feng eGao, AKM Rohul Amin, Sayaka eMino, Satoshi eNakagawa, Toko eSawabe, Ramesh eKumar, Yohei eFukui, Masataka eSatomi, Ryoji eMatsushima, Fabiano L. Thompson, Bruno eGomez-Gil, Richard eChristen, Richard eChristen, Fumito eMaruyama, Ken eKurokawa, Testuya eHayashi   +18 more
doaj   +1 more source