Results 61 to 70 of about 1,894,988 (266)

Relative evolutionary rate inference in HyPhy with LEISR [PDF]

PeerJ, 2018
We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced “laser”), a tool to infer relative evolutionary rates from protein and nucleotide data, implemented in HyPhy.
Stephanie J. Spielman, Sergei L. Kosakovsky Pond   +1 more
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Protein sequence analysis in the context of drug repurposing

BMC Medical Informatics and Decision Making
Motivation Drug repurposing speeds up the development of new treatments, being less costly, risky, and time consuming than de novo drug discovery. There are numerous biological elements that contribute to the development of diseases and, as a result, to ...
Natalia García Sánchez, Esther Ugarte Carro, Lucía Prieto-Santamaría, Alejandro Rodríguez-González   +3 more
doaj   +1 more source

AlignScape, displaying sequence similarity using self-organizing maps

Frontiers in Bioinformatics
The current richness of sequence data needs efficient methodologies to display and analyze the complexity of the information in a compact and readable manner.
Isaac Filella-Merce, Isaac Filella-Merce, Vincent Mallet, Eric Durand, Michael Nilges, Guillaume Bouvier, Riccardo Pellarin, Riccardo Pellarin   +7 more
doaj   +1 more source

Prediction of bacterial E3 ubiquitin ligase effectors using reduced amino acid peptide fingerprinting [PDF]

PeerJ, 2019
Background Although pathogenic Gram-negative bacteria lack their own ubiquitination machinery, they have evolved or acquired virulence effectors that can manipulate the host ubiquitination process through structural and/or functional mimicry of host ...
Jason E. McDermott, John R. Cort, Ernesto S. Nakayasu, Jonathan N. Pruneda, Christopher Overall, Joshua N. Adkins   +5 more
doaj   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

HCMV Envelope Glycoprotein Diversity Demystified

Frontiers in Microbiology, 2019
Human cytomegalovirus (HCMV) is the leading viral cause of congenital birth defects and is responsible for morbidity and mortality in immunosuppressed individuals.
Mathilde Foglierini, Mathilde Foglierini, Jessica Marcandalli, Laurent Perez   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A primary sequence analysis of the ARGONAUTE protein family in plants.

Frontiers in Plant Science, 2016
Small RNA (sRNA)-mediated gene silencing represents a conserved regulatory mechanism controlling a wide diversity of developmental processes through interactions of sRNAs with proteins of the ARGONAUTE (AGO) family.
Daniel Rodriguez-Leal, Amanda Castillo-Cobián, Isaac Rodriguez-Arévalo, Jean-Philippe Vielle-Calzada   +3 more
doaj   +1 more source