Results 201 to 210 of about 31,098,092 (376)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Discovering functional sequences with RELICS, an analysis method for CRISPR screens

open access: gold, 2020
Patrick C. Fiaux   +4 more
openalex   +1 more source

Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone alpha-subunit gene. [PDF]

open access: bronze, 1992
W E Schoderbek   +4 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2004
J. Syka   +4 more
semanticscholar   +1 more source

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