Results 271 to 280 of about 31,098,092 (376)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison. [PDF]

J Biol Chem
Bonacci T, Bolhuis DL, Brown NG, Emanuele MJ.   +3 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Complete genome sequence analysis of Sarbecovirus (severe acute respiratory syndrome-related coronaviruses) from Zimbabwean insectivorous bats. [PDF]

BMC Genomics
Chidoti V, Loisier A, Zinyakasa T, Bourgarel M, Pinarello V, Matope G, Chiweshe N, Missé D, Mwandiringana E, De Nys H, Liégeois F.   +10 more
europepmc   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Palliative care pathways in Amyotrophic Lateral Sclerosis (ALS): a sequence analysis of health claims data. [PDF]

BMC Palliat Care
Schmidt R, Slotina E, Meissner F, Metelmann M, Ilse B, Vogt V, Freytag A.   +6 more
europepmc   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Using ChatGPT as a tool for training nonprogrammers to generate genomic sequence analysis code. [PDF]

Biochem Mol Biol Educ
Delcher HA, Alsatari ES, Haastrup AI, Naaz S, Hayes-Guastella LA, McDaniel AM, Clark OG, Katerski DM, Prinsloo FO, Roberts OR, Shaddix MA, Sullivan BN, Swan IM, Hartsell EM, DeMeis JD, Paudel SS, Borchert GM.   +16 more
europepmc   +1 more source

Quantitative Assessment of Randomized DNA Base Sequences Using Multi‐Model Physical Analysis for High‐Fidelity Data Storage [PDF]

Seongjun Seo, Thi Hong Nhung Vu, Anshula Tandon, Su-Youn Park, Su-Youn Park, Thi Bich Ngoc Nguyen, Shinsuke Kawai, Sung Ha Park, Sung Ha Park   +8 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source