Results 131 to 140 of about 5,890,604 (383)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Reconciling competing hypotheses regarding flower–leaf sequences in temperate forests for fundamental and global change biology [PDF]

, 2020
D. M. Buonaiuto, Ignacio Morales‐Castilla, E. M. Wolkovich   +2 more
openalex   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

A two-base encoded DNA sequence alignment problem in computational biology [PDF]

, 2009
The recent introduction of instruments capable of producing millions of DNA sequence reads in a single run is rapidly changing the landscape of genetics.
Chang, Jen-Mei, Drakes, Chiaka, Huang, Erya, Langat, Deidrey, McGrath, Joseph, Morabito, Mark, Pacheco, Jose, Rodriguez, Nancy, Salazar, Daniel, Vemuri, Rao, Vu, Man, Wadhar, Hem, Wu, Qin   +12 more
core  

Guide for phenotype-specific profiling of DNA G-quadruplex-regulated genes

STAR Protocols
Summary: DNA G-quadruplex (G4) is a non-canonical four-stranded secondary structure that has been shown to play a role in epigenetic modulation of gene expression.
Zhuoyang Zhao, Jianru Wang, Huichuan Yu, Xiaolin Wang   +3 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Long-read sequence assembly of the gorilla genome

Science, 2016
Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al.
D. Gordon, J. Huddleston, Mark J. P. Chaisson, C. Hill, Zev N. Kronenberg, Katherine M. Munson, Maika Malig, A. Raja, Ian T. Fiddes, L. Hillier, Christopher Dunn, Carl A. Baker, J. Armstrong, M. Diekhans, B. Paten, J. Shendure, R. Wilson, D. Haussler, C. Chin, E. Eichler   +19 more
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Topological network alignment uncovers biological function and phylogeny

, 2009
Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact.
Cook S., Flannick J., Kuchaiev O., Kuchaiev O., Memišević V., Nataša Pržulj, Oleksii Kuchaiev, Pržulj N., Singh R., Singh R., Snijders T. A., Tijana Milenković, Vesna Memišević, Wayne Hayes, Wentz-Hunter K., Zhang Y.   +15 more
core   +2 more sources