Results 131 to 140 of about 1,274,222 (313)
Segmenting DNA sequence into words based on statistical language model
, 2012 This paper presents a novel method to segment/decode DNA sequences based on n-gram statistical language model. Firstly, we find the length of most DNA “words” is 12 to 15 bps by analyzing the genomes of 12 model species.
Wang Liang
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Improving phonetic alignment by handling secondary sequence structures [PDF]
, 2014 In traditional alignment analyses, sequences are only compared with regard to their primary structure. Here, the term primary structure refers to the order order of segments, whereby segments are understood as the smallest units of a sequence which ...
List, Johann-Mattis
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Synthetic Biology Open Language (SBOL) Version 2.1.0
Journal of Integrative Bioinformatics, 2016 Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems.
Beal Jacob +22 more
doaj +1 more source
Be aware of behaviour: learning and teaching behavioural biology in secondary education
, 2012 Learning and teaching New Biology requires new educational approaches to acquire knowledge of the (new) biology, competences to understand complex systems, and new learning and teaching strategies.
van Moolenbroek, J. +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2014 Biological data exists in several layers from genome sequence to networks and beyond. Information that comes from environment passes through layers of viscosity within organisms and is transformed into an output released back into the environment.
Dhar, Pawan K; Centre for Systems and Synthetic Biology, Department of Computational Biology and Bioinformatics, University of Kerala, Trivandrum, Kerala
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