Results 171 to 180 of about 5,758,485 (356)

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

ANNOUNCING COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL: NOT JUST ANOTHER OPEN-ACCESS JOURNAL

open access: yesComputational and Structural Biotechnology Journal, 2012
Gianni Panagiotou
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Protocol for constructing glycan biosynthetic networks using glycowork

open access: yesSTAR Protocols
Summary: Glycans, present across all domains of life, comprise a wide range of monosaccharides assembled into complex, branching structures. Here, we present an in silico protocol to construct biosynthetic networks from a list of observed glycans using ...
Jon Lundstrøm   +2 more
doaj  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Cells, shared memory and breaking the PTM code

open access: yesMolecular Systems Biology, 2012
Pau Creixell, Rune Linding
doaj   +1 more source

Protocol for genetic load analysis in caribou using a modified genomic evolutionary rate profiling

open access: yesSTAR Protocols
Summary: Here, we present a protocol to analyze genetic load in caribou (Rangifer tarandus) using a modified version of the genomic evolutionary rate profiling (GERP) program.
Rebecca S. Taylor   +3 more
doaj  

Inferences on the evolution of the ascorbic acid synthesis pathway in insects using Phylogenetic Tree Collapser (PTC), a tool for the automated collapsing of phylogenetic trees using taxonomic information

open access: yesJournal of Integrative Bioinformatics
When inferring the evolution of a gene/gene family, it is advisable to use all available coding sequences (CDS) from as many species genomes as possible in order to infer and date all gene duplications and losses.
Glez-Peña Daniel   +4 more
doaj   +1 more source

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