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Comparative biology: beyond sequence analysis
Current Opinion in Biotechnology, 2007Comparative analysis is a fundamental tool in biology. Conservation among species greatly assists the detection and characterization of functional elements, whereas inter-species differences are probably the best indicators of biological adaptation. Traditionally, comparative approaches were applied to the analysis of genomic sequences.
Naama Barkai, Yonatan Bilu, Itay Tirosh
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T-Coffee: A novel method for fast and accurate multiple sequence alignment.
Journal of Molecular Biology, 2000We describe a new method (T-Coffee) for multiple sequence alignment that provides a dramatic improvement in accuracy with a modest sacrifice in speed as compared to the most commonly used alternatives.
C. Notredame, D. Higgins, J. Heringa
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Genome annotation: from sequence to biology [PDF]
Nature Reviews Genetics, 2001 The genome sequence of an organism is an information resource unlike any that biologists have previously had access to. But the value of the genome is only as good as its annotation. It is the annotation that bridges the gap from the sequence to the biology of the organism.
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Predicting subcellular localization of proteins based on their N-terminal amino acid sequence.
Journal of Molecular Biology, 2000A neural network-based tool, TargetP, for large-scale subcellular location prediction of newly identified proteins has been developed. Using N-terminal sequence information only, it discriminates between proteins destined for the mitochondrion, the ...
O. Emanuelsson +3 more
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Fruits of Genome Sequences for Biology
Science, 2011It is nearly impossible for today's students to think about biology without DNA ...
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Centromeres: Sequences, Structure, and Biology
2012Although technological advances have continued to change the speed, cost, and number of plant genomes sequenced (see Flagel and Blackman 2012, this volume), parts of genomes remain to be sequenced and explored. Even the best-sequenced plant genomes, including Arabidopsis thaliana and rice, are missing 7–8% of their total genomic information (Kaul et al.
Jiming Jiang, Cory D. Hirsch
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Potyvirus serology, sequences and biology
1992Amino acid sequences of the cytoplasmic cylindrical inclusion protein (CIP), large nuclear inclusion protein (NIb), and coat protein (CP) of potyviruses were re-examined in light of reported serological relationships, and correlated with known and deduced biological functions. No obvious correlations were observed between either amino acid sequences or
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A Sequence for Biology Studies
Science, 1966As another parent of two children who have bad high school biology (both had the Biological Sciences Curriculum Study Blue Version course), I would like to comment on Branson's letter (28 Oct.). My children have both come away, instilled with enthusiasm for the study of biology, with the feeling that it's a science, that it's understandable ...
Walter F. Cannon, M. W. Burke-Gaffney
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Molecular Plant-Microbe Interactions, 2012
Nicotiana benthamiana is a widely used model plant species for the study of fundamental questions in molecular plant-microbe interactions and other areas of plant biology.
A. Bombarely +5 more
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Nicotiana benthamiana is a widely used model plant species for the study of fundamental questions in molecular plant-microbe interactions and other areas of plant biology.
A. Bombarely +5 more
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Next-generation sequencing transforms today's biology [PDF]
Nature Methods, 2007 A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger ...
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