Results 51 to 60 of about 1,667,563 (261)

SuiteMSA: visual tools for multiple sequence alignment comparison and molecular sequence simulation

BMC Bioinformatics, 2011
Background Multiple sequence alignment (MSA) plays a central role in nearly all bioinformatics and molecular evolutionary applications. MSA reconstruction is thus one of the most heavily scrutinized bioinformatics fields.
Strope Cory L, Anderson Catherine L, Moriyama Etsuko N   +2 more
doaj   +1 more source

Finite width model sequence comparison [PDF]

Physical Review E, 2004
Sequence comparison is a widely used computational technique in modern molecular biology. In spite of the frequent use of sequence comparisons the important problem of assigning statistical significance to a given degree of similarity is still outstanding.
Bundschuh, Ralf, Chia, Nicholas
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Comparison of metagenomic samples using sequence signatures

BMC Genomics, 2012
Background Sequence signatures, as defined by the frequencies of k-tuples (or k-mers, k-grams), have been used extensively to compare genomic sequences of individual organisms, to identify cis-regulatory modules, and to study the evolution of regulatory ...
Jiang Bai, Song Kai, Ren Jie, Deng Minghua, Sun Fengzhu, Zhang Xuegong   +5 more
doaj   +1 more source

Massive Sequence Comparisons as a Help in Annotating Genomic Sequences [PDF]

Genome Research, 2001
An all-by-all comparison of all the publicly available protein sequences from plants has been performed, followed by a clusterization process. Within each of the 1064 resulting clusters—containing sequences that are orthologous as well as paralogous—the sequences have been submitted to a pyramidal classification and their domains delineated by an ...
Louis, Alexandra, Ollivier, Emmanuelle, Aude, Jean-Christophe, Risler, Jean Loup   +3 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sequence Comparison in Historical Linguistics

, 2021
The comparison of sound sequences (words, morphemes) constitutes the core of many techniques and methods in historical linguistics. With the help of these techniques, corresponding sounds can be determined, historically related words can be identified, and the history of languages can be uncovered.
openaire   +3 more sources

Sequence comparison on the connection machine

Concurrency: Practice and Experience, 1991
AbstractWe give two parallel algorithms for sequence comparison on the Connection Machine 2 (CM‐2). The specific comparison measure we compute is theedit distance: given a finite alphabet ∑ and two input sequencesXϵ ∑+andYϵ ∑+the edit distanced(X,Y)is the minimum cost of transformingXintoYvia a series of weighted insertions, deletions and substitutions
Atallah, Mikhail J., McFaddin, Scott
openaire   +2 more sources