Results 61 to 70 of about 3,098,423 (296)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Quaternion Convolutional Neural Networks for End-to-End Automatic Speech Recognition [PDF]

open access: yes, 2018
Recently, the connectionist temporal classification (CTC) model coupled with recurrent (RNN) or convolutional neural networks (CNN), made it easier to train speech recognition systems in an end-to-end fashion.
Bengio, Yoshua   +6 more
core   +3 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

Contribution of primordial binary evolution to the two blue-straggler sequences in globular cluster M30

open access: yes, 2017
Two blue-straggler sequences discovered in globular cluster M30 provide a strong constraint on the formation mechanisms of blue stragglers. We study the formation of the blue-straggler binaries through binary evolution, and find that binary evolution can
Chen, Xuefei   +3 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

Describing Component Collaboration Using Goal Sequences [PDF]

open access: yes, 2008
Services are normally not performed by a single component, but result from the collaboration of several distributed components. Their precise specification and validation require complex models, where the intention of the service is easily lost in the detail.
Carrez, Cyril   +2 more
openaire   +3 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Laying pattern parameters in broiler breeder hens and intrasequence changes in egg composition

open access: yesCzech Journal of Animal Science, 2010
The aim of the study was to analyze the pattern of oviposition time in laying sequences in broiler breeder hens and to determine a relationship between egg position in the sequence and egg quality. The sequences were described using mean oviposition time
M. Gumulka, E. Kapkowska, D. Maj
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Brunnian links are determined by their complements

open access: yes, 2001
If L_1 and L_2 are two Brunnian links with all pairwise linking numbers 0, then we show that L_1 and L_2 are equivalent if and only if they have homeomorphic complements. In particular, this holds for all Brunnian links with at least three components. If
Brian S Mangum   +8 more
core   +1 more source

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