Results 71 to 80 of about 10,525,702 (295)

Research on Assembly Sequence Planning of Large Cruise Ship Cabins Based on Improved Genetic Algorithm

Biomimetics
In the construction process of large cruise ships, there are numerous cabin components, and the number of assembly sequences will experience a “combinatorial explosion”, which will become a complex NP hard problem.
Liyang Ju, Xiaoyuan Wu, Yixi Zhao, Jianfeng Liu, Kun Liu   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Unified Modeling Language Quantitative Measures Based on a Behavioural Model [PDF]

مجلة التربية والعلم
Behavioral diagrams in Unified Modeling Language reflect the interaction between system components and give a comprehensive description and visualization of the system during the design phase. One of the most important behavioral diagrams is the sequence
Marwah Dabdawb
doaj   +1 more source

The genetic component of preeclampsia: A whole-exome sequencing study

PLOS ONE, 2018
Preeclampsia is a major cause of maternal and perinatal deaths. The aetiology of preeclampsia is largely unknown but a polygenetic component is assumed. To explore this hypothesis, we performed an in-depth whole-exome sequencing study in women with (cases, N = 50) and without (controls, N = 50) preeclampsia.
Anette Tarp Hansen, Jens Magnus Bernth Jensen, Anne-Mette Hvas, Mette Christiansen   +3 more
openaire   +6 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Spectral Method of Measuring of Changes in Time Intervals between Periodic Pulse Sequences

Приборы и методы измерений, 2019
Methods of measuring delay time between periodic sequences of pulses are mostly based on the considered parameter direct measurement. The main disadvantage of this approach is the difficulty of ensuring the measurements accuracy in the noise conditions ...
A. A. Sheinikov, A. V. Isaev, V. V. Zelenko, Yu. V. Sukhodolov   +3 more
doaj   +1 more source

On optimal operational sequence of components in a warm standby system

Journal of Applied Probability, 2018
Abstract We consider an open problem of obtaining the optimal operational sequence for the 1-out-of-n system with warm standby. Using the virtual age concept and the cumulative exposure model, we show that the components should be activated in accordance with the increasing sequence of their lifetimes.
Maxim Finkelstein, Nil Kamal Hazra, Ji Hwan Cha   +2 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source