Results 91 to 100 of about 10,525,702 (295)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Novel hybrid data-driven modeling based on feature space reconstruction and multihead self-attention gated recurrent unit: applied to PM2.5 concentrations prediction

Scientific Reports
In response to the problem of neglecting the periodic and global characteristics of sequence data when predicting PM2.5 concentrations via machine learning models, a PM2.5 concentrations prediction model based on feature space reconstruction and ...
Xiaoxin Yue, Yulong Bai, Qinghe Yu, Lin Ding, Wei Song, Wenhui Liu, Huhu Ren, Qi Song   +7 more
doaj   +1 more source

Research on a Faulty Line Selection Method Based on the Zero-Sequence Disturbance Power of Resonant Grounded Distribution Networks

Energies, 2019
For fast and accurate faulty line selection (FLS) in single phase-to-ground (SPG) faults for resonant grounded distribution networks (RGDNs), this paper proposes a FLS method based on zero-sequence power characteristics.
Wenquan Shao, Jie Bai, Yuan Cheng, Zhihua Zhang, Ning Li   +4 more
doaj   +1 more source

Open Sequence Components of a Closed Ecology

The American Biology Teacher, 1963
Among the items necessary for life support in a closed ecological system designed for space travel one may list oxygen, water, food, and energy. The production of oxygen for breathing has apparently been claimed by photosynthologists, and the production of drinking water by a variety of engineers.
Robert G. Tischer, Barbara P. Tischer
openaire   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Complete mitochondrial genome sequence analysis revealed double matrilineal components in Indian Ghoongroo pigs

Scientific Reports
This research aimed to characterize the mitochondrial genome of the Ghoongroo (GH) pig, a notable breed in India, along with its crossbred varieties, to elucidate their matrilineal components, evolutionary history, and implications for conservation ...
Pranab Jyoti Das, Satish Kumar, Manasee Choudhury, Seema Rani Pegu, K. Meera, Rajib Deb, Sunil Kumar, Santanu Banik, Vivek Kumar Gupta   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ON THE COMPONENTS OF SOME SPECIAL SEQUENCES

, 2019
The Fibonacci, Lucas, Pell, Pell-Lucas, Jacobsthal and Jacobsthal-Lucas sequences {Fn}, {Ln}, {Pn}, {P Ln}, {Jn} and {JLn} are defined by two order recurrences for n ≥ 0, respectively, Fn+2 = Fn+1 + Fn, Ln+2 = Ln+1 + Ln, Pn+2 = 2Pn+1 + Pn, P Ln+2 = 2P Ln+1 + P Ln, Jn+2 = Jn+1 + 2Jn, JLn+2 = JLn+1 + 2JLn, with the initial conditions, respectively, F0 = 0,
Dişkaya, Orhan, Menken, Hamza, Çuvalcıoğlu, Gökhan   +2 more
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source