Results 171 to 180 of about 3,273,751 (230)

Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

Angewandte Chemie International Edition, EarlyView.
Used in search of novel allosteric sites in the serine/threonine kinase p38α, NMR spectroscopy reveals a dynamic coupling between the catalytic and lipid pockets. The findings uncover a motional interdependence that links distant regions of the enzyme, highlighting the lipid pocket as a promising site for allosteric intervention.
Sara Medina Gómez, Laurin T. Homberg, Mike Bührmann, Daniel Rauh, Rasmus Linser   +4 more
wiley   +1 more source

Effects of emergency rescue clothing on wearers' physiological and perceptual responses in hot-humid environments. [PDF]

Front Public Health
Qian Y, Yuan M, Yan K, Li Y, Wang X, Wu H.   +5 more
europepmc   +1 more source

Controlled Delivery and Light‐Induced Release of Magic Spot Nucleotides in Escherichia coli

Angewandte Chemie International Edition, EarlyView.
We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp, Patrick Moser, Anselm Schwoerbel, Xinwei Liu, Johannes Freitag, Pinku Sarmah, Isabel Prucker, Robert Zscherp, Xuan Wang, Philipp Klahn, Hans‐Georg Koch, Gert Bange, Henning J. Jessen   +12 more
wiley   +1 more source

Reduced linguistic coherence in psychosis defies semantic similarity accounts and relates to altered large-scale cortical hierarchy. [PDF]

Sci Rep
He R, Grodzki R, Altay N, Aston B, Alonso-Sánchez MF, Homan P, Sommer I, Palaniyappan L, Hinzen W.   +8 more
europepmc   +1 more source

Metal‐Free Scission of the NO+ Triple Bond

Angewandte Chemie International Edition, EarlyView.
Breaking bonds: The reaction between NO[Al(ORF)4] (RF = C(CF3)3) and the diphosphane PNPtBu (2,6‐bis(di‐tert‐butylphosphino‐methyl)pyridine) leads to the direct and complete cleavage of the NO+ triple bond, one of the strongest chemical bonds known. The mechanism of this reaction was studied using quantum chemical calculations and NMR spectroscopic ...
Julie Willrett, Harald Scherer, Burkhard Butschke, Ingo Krossing   +3 more
wiley   +1 more source

LGBTQIA+ STEM Day 2025: An interview with Fabrice Roux. [PDF]

Commun Biol
europepmc   +1 more source

Correspondence: On the "2-minute rule". [PDF]

Resusc Plus
Stewart JA.
europepmc   +1 more source

The IQ-compete assay for measuring mitochondrial protein import efficiencies in living yeast cells. [PDF]

FEBS Lett
Hoffman Y, Egeler A, Rödl S, Herrmann JM.   +3 more
europepmc   +1 more source

Oscillating diachronic mobility patterns in prehistoric Eastern Sudan revealed by ⁸⁷Sr/⁸⁶Sr isotope analysis. [PDF]

Sci Rep
Capasso G, Sperduti A, Idriss Ahmed H, Cipriani A, Bondioli L, Nava A, Lugli F, Manzo A.   +7 more
europepmc   +1 more source

Ontogenetic changes and sexual dimorphism in the cranium and mandible of the Atlantic walrus (Odobenus rosmarus rosmarus L.)

The Anatomical Record, EarlyView.
Abstract Walruses have been an important subsistence and cultural resource for humans and have been exploited for millennia across their distribution. This exploitation has contributed to severe declines in several populations and local extirpations.
Katrien Dierickx, Oliver Kersten, Youri van den Hurk, Brenna A. Frasier, Richard Sabin, Bastiaan Star, James H. Barrett   +6 more
wiley   +1 more source