Results 51 to 60 of about 367,087 (259)

Discrete Sequence Production With and Without a Pause: The Role of Cortex, Basal Ganglia and Cerebellum

Frontiers in Human Neuroscience, 2013
Our sensorimotor experience unfolds in sequences over time. We hypothesize that the processing of movement sequences with and without a temporal pause will recruit distinct but cooperating neural processes, including cortico-striatal and cortico ...
Anne-Lise eJouen, Willem B Verwey, Jurjen eVan Der Helden, Christian eScheiber, Remi eNeveu, Peter Ford Dominey, Jocelyne eVentre-Dominey   +6 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effects of dopamine medication on sequence learning with stochastic feedback in Parkinson's disease

Frontiers in Systems Neuroscience, 2010
A growing body of evidence suggests that the midbrain dopamine system plays a key role in reinforcement learning and disruption of the midbrain dopamine system in Parkinson's disease (PD) may lead to deficits on tasks that require learning from feedback.
Moonsang Seo, Moonsang Seo, Mazda Beigi, Marjan Jahanshahi, Bruno B Averbeck, Bruno B Averbeck   +5 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Organizing Sequential Memory in a Neuromorphic Device Using Dynamic Neural Fields

Frontiers in Neuroscience, 2018
Neuromorphic Very Large Scale Integration (VLSI) devices emulate the activation dynamics of biological neuronal networks using either mixed-signal analog/digital or purely digital electronic circuits.
Raphaela Kreiser, Dora Aathmani, Ning Qiao, Giacomo Indiveri, Yulia Sandamirskaya   +4 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

How the cerebellum learns to build a sequence

eLife, 2018
Rabbits can learn the biological analogue of a simple recursive function by relying only on the neurons of the cerebellum.
Reza Shadmehr
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Detection of Violent Scenes in Cartoon Movies Using a Deep Learning Approach

IEEE Access
Cartoon movies are a primary source of entertainment for children. However, concerns arise when these movies inadvertently expose children to violent scenes.
Noreen Fayyaz Khan, Sareer Ul Amin, Zahoor Jan, Changhui Yan   +3 more
doaj   +1 more source